Using a Smartphone to Detect Cancer

Giller, Geoffrey

doi:10.1038/scientificamerican0514-28a

Cited by 6 publications

(5 citation statements)

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“…8 The wide availability and popularity of smartphones, particularly in the developing countries, make this device promising as a low-cost, portable, and capable theragnostic cancer technology for global health. [9][10][11] Building on previous preliminary findings, 12 we report here an evaluation of this simple and low-cost fluorescence imaging approach for guidance and monitoring of PDT treatment in the clinic.…”

Section: Introductionmentioning

confidence: 99%

Clinical evaluation of smartphone-based fluorescence imaging for guidance and monitoring of ALA-PDT treatment of early oral cancer

et al. 2020

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Clinical evaluation of smartphone-based fluorescence imaging for guidance and monitoring of ALA-PDT treatment of early oral cancer," J. AbstractSignificance: India has one of the highest rates of oral cancer incidence in the world, accounting for 30% of reported cancers. In rural areas, a lack of adequate medical infrastructure contributes to unchecked disease progression and dismal mortality rates. Photodynamic therapy (PDT) has emerged as an effective modality with potential for treating early stage disease in resourcelimited settings, while photosensitizer fluorescence can be leveraged for treatment guidance.Aim: Our aim was to assess the capability of a simple smartphone-based device for imaging 5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) fluorescence for treatment guidance and monitoring as part of an ongoing clinical study evaluating low-cost technology for ALA-based PDT treatment of early oral cancer.Approach: A total of 29 subjects with <2 cm diameter moderately/well-differentiated microinvasive (< 5 mm depth) oral squamous cell carcinoma lesions (33 lesions total, mean area ∼1.23 cm 2 ) were administered 60 mg∕kg ALA in oral solution and imaged before and after delivery of 100 J∕cm 2 total light dose to the lesion surface. Smartphone-based fluorescence and white light (WL) images were analyzed and compared with ultrasound (US) imaging of the same lesions.Results: We present a comparative analysis of pre-and post-treatment fluorescence, WL, and US images of oral lesions. There was no significant difference in the distribution of lesion widths measured by fluorescence and US (mean widths of 14.5 and 15.3 mm, respectively) and linear regression shows good agreement (R 2 ¼ 0.91). In general, PpIX fluorescence images obtained prior to therapeutic light delivery are able to resolve lesion margins while dramatic photobleaching (∼42%) is visible post-treatment. Segmentation of the photobleached area confirms the boundaries of the irradiated zone. Conclusions:A simple smartphone-based approach for imaging oral lesions is shown to agree in most cases with US, suggesting that this approach may be a useful tool to aid in PDT treatment guidance and monitoring photobleaching as part of a low-cost platform for intraoral PDT.

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Section: Introductionmentioning

confidence: 99%

Clinical evaluation of smartphone-based fluorescence imaging for guidance and monitoring of ALA-PDT treatment of early oral cancer

et al. 2020

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“…This, combined with the recent developments of fluorescence imaging applications utilizing smartphones 11 12 , which have become widely available and popular even in developing countries where other resources may be scarce 13 , suggests the capacity for PDT as a low-cost, portable, theranostic cancer technology for global health. Indeed, the simultaneous availability and built-in processing and image acquisition capabilities of smartphones, have led to increasing recognition of these ubiquitous mobile devices as a platform for cancer technologies for global health 14 15 .…”

mentioning

confidence: 99%

Low-cost photodynamic therapy devices for global health settings: Characterization of battery-powered LED performance and smartphone imaging in 3D tumor models

Hempstead

Jones

Ziouche

et al. 2015

Sci Rep

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A lack of access to effective cancer therapeutics in resource-limited settings is implicated in global cancer health disparities between developed and developing countries. Photodynamic therapy (PDT) is a light-based treatment modality that has exhibited safety and efficacy in the clinic using wavelengths and irradiances achievable with light-emitting diodes (LEDs) operated on battery power. Here we assess low-cost enabling technology to extend the clinical benefit of PDT to regions with little or no access to electricity or medical infrastructure. We demonstrate the efficacy of a device based on a 635 nm high-output LED powered by three AA disposable alkaline batteries, to achieve strong cytotoxic response in monolayer and 3D cultures of A431 squamous carcinoma cells following photosensitization by administering aminolevulinic acid (ALA) to induce the accumulation of protoporphyrin IX (PpIX). Here we characterize challenges of battery-operated device performance, including battery drain and voltage stability specifically over relevant PDT dose parameters. Further motivated by the well-established capacity of PDT photosensitizers to serve as tumour-selective fluorescence contrast agents, we demonstrate the capability of a consumer smartphone with low-cost add-ons to measure concentration-dependent PpIX fluorescence. This study lays the groundwork for the on-going development of image-guided ALA-PDT treatment technologies for global health applications.

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“…7 Recently, a smartphone with fluorescence imaging capability has been used as a low-cost device for pre-malignant oral screening. 8 Since widely availability and popularity of smartphone, particularly in the developing countries, this combination suggested as a low-cost, portable and capable theragnostic cancer technology for global health [9][10][11] Here, we initiated the low-cost based fluorescence imaging in the clinical settings for guidance and monitoring of PDT treatment and simulate the rural settings where afford the advanced cost-effective monitoring are an economic burden.…”

Section: Introductionmentioning

confidence: 99%

Clinical evaluation of smartphone-based fluorescence imaging for guidance and monitoring of ALA PDT

Khan

Hussain

Khan

et al. 2019

17th International Photodynamic Association World Congress

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India has one of the highest rates of oral cancer incidence in the world, with an estimated 80,000 new cases per year, accounting for 30% of reported cancers. In rural areas, a lack of adequate medical infrastructure contributes to unchecked disease progression and dismal mortality rates. PDT emerges as a potential modality which can be implemented in resource limited settings, while photosensitizer fluorescence can be leveraged for treatment guidance. Here, as part of an ongoing clinical study evaluating low-cost technology for ALA PDT treatment, we evaluated the capability of a simple smartphone-based device for imaging ALA-induced PpIX fluorescence for treatment guidance and monitoring. The imaging device itself consists of an annulus of 405nm LEDs for PpIX excitation with emission filter in the center mounted over the phone camera. 21 subjects having <2 cm diameter (mean size; ∼ 1.29 cm 2) lesions with micro-invasive (≤ 5mm. depth) moderately/well-differentiated squamous cell carcinoma were administered 60 mg/kg ALA in oral solution and imaged before and after delivery of 100 J/cm 2 total light dose to the lesion surface. We will present comparative analysis of pre-and post-treatment fluorescence, white light (WL), and ultrasound images. In general, PpIX fluorescence images obtained prior to therapeutic light delivery are able to resolve lesion margins while dramatic photobleaching in post-treatment images confirms the irradiated zone. Overall this approach is able to generate sufficient fluorescence contrast for treatment guidance and monitoring photobleaching while the use of a smartphone-based device provides a low-cost, widely available platform with potential for telemedicine integration.

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Using a Smartphone to Detect Cancer

Cited by 6 publications

References 0 publications

Clinical evaluation of smartphone-based fluorescence imaging for guidance and monitoring of ALA-PDT treatment of early oral cancer

Clinical evaluation of smartphone-based fluorescence imaging for guidance and monitoring of ALA-PDT treatment of early oral cancer

Low-cost photodynamic therapy devices for global health settings: Characterization of battery-powered LED performance and smartphone imaging in 3D tumor models

Clinical evaluation of smartphone-based fluorescence imaging for guidance and monitoring of ALA PDT

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