Using a “systems therapeutic for physiological renormalization” approach to vaccine development. Covid-19 as an example

Abstract

Current vaccines for Covid-19 have failed to prevent the disease from spreading and have allowed more transmissible and virulent variants to form through mutations and recombinations as they replicate during the massive spread of the virions. Here I suggest using a “systems therapeutic” vaccine and dosing strategy to induce “physiological renormalization” to induce mimicry in the innate and adaptive immune systems in the respiratory tracts and sera, similar to that when the body encounters the natural infectious agent.

Covid-19 Vaccine-Induced Autoimmune Disease: Case Study with Therapeutic and Dietary Regimen

“…A "booster" vaccine against the new Omicron variant is now being designed. Instead of a vaccine inducing a supranormal antibody response measured in the blood, broader immunity induced in the respiratory tracts as well as the blood has been suggested as a new vaccine strategy (Maguire, 2022). This would mean a vaccine that induces a broader immune response than that simply aimed at the spike proteins, and delivering the vaccine IM as well as intranasally.…”

“…Neutralizing autoantibodies may also appear after SARS-CoV-2 infection, in which case they might instead enable viral persistence, the formation of a viral reservoir and long COVID. Maguire (2022) has suggested a means to develop vaccines that better prevents the spread of virions and also reduce the probability of vaccine injury. However, current Covid-19 vaccine induced autoimmune disease can be severe in adults (de Brujin et al, 2021;Kaulen et al, 2022) and children (Buckhorn et al, 2021), leading to hospitalization.…”

Covid-19 Vaccine-Induced (IgG4) Autoimmune Disease: Case Study with Therapeutic and Dietary Regimen

“…That is, those who were mRNA-vaccinated but had no previous Covid-19 infection (mRNA ->INF) or who had no Covid-19 infection before or after vaccination (no INF), had high levels of IgG4. Maguire (2022) has suggested a means to develop vaccines that better prevents the spread of virions and also reduce the probability of vaccine injury. However, current Covid-19 vaccine induced autoimmune disease can be severe in adults (de Brujin et al, 2021;Kaulen et al, 2022) and children (Buckhorn et al, 2021), leading to hospitalization.…”