Using a two-step method of surface mechanical attrition treatment and calcium ion implantation to promote the osteogenic activity of mesenchymal stem cells as well as biomineralization on a β-titanium surface

Huang, Run; Hao, Yufei; Pan, Yusong; Pan, Cheng‐Ling; Tang, Xiaolong; Huang, Lei; Du, Chao; Yue, Rongcai; Cui, Diansheng

doi:10.1039/d2ra00032f

Cited by 8 publications

(3 citation statements)

References 66 publications

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“…143) A limited surface hardening was observed for an orthopedic TiNbSn alloys after SMAT but SMAT enhanced the cell proliferation rate and, more importantly, the osteogenic differentiation of stem cells. 107) SMAT treatment followed by calcium ion implantation has been tested on the Ti25Nb 3Mo2Sn3Zr ¢-Ti alloy by Huang et al 144) The SMATed samples showed improved hydrophilicity compared to the untreated samples. Subsequent Ca ion implantation further improved wettability.…”

Section: Titanium Alloysmentioning

confidence: 99%

Surface Severe Plastic Deformation for Improved Mechanical/Corrosion Properties and Further Applications in the Bio-Medical and Hydrogen Sectors

2023

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Various techniques enabling surface severe plastic deformation (SSPD) have been developed or optimised over the past years. This manuscript presents a broad overview of recent developments in the field of SSPD and its application that take advantages of having a deformed gradient surface with both (i) higher strength and (ii) an improved "reactivity". First, the principle and technological advantages/ disadvantages of several SSPD technologies, involving either guided or non-directional mechanical impacts, are recalled. Then, after a short recall on the nature of the structure the modified surface formed under SSPD, the effects of the processing parameters and temperature of deformation on the surface roughness and subsurface microstructure modifications are illustrated with a particular emphasis on the surface mechanical attrition treatment (SMAT) and ultrasonic shot peening (USP) techniques deriving from the traditional pre-strain shot peening. The effect of these surface and sub-surface modifications on the mechanical properties, and in particular the fatigue response, are recalled with a special emphasis on the surface integrity and potential over shot peening. Then, the manuscript concentrates on the effect of the surface enhanced diffusion of chemical species induced by the presence of structural defects to modify the corrosion behaviour and enhance the potential assisted SSPD + thermo-chemically "duplex" treatments. In these cases, in addition to induce grain refinement and dislocations, the importance of controlling some potential surface contamination is stressed. Finally, the manuscript terminates by illustrating some new research studies on potential applications for the challenges in the hydrogen sector for its solid-state storage and the protection of mechanical infrastructures as well as for bio-medical applications with biocompatible Ti-based alloys and biodegradable Mg-based ones.

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Section: Titanium Alloysmentioning

confidence: 99%

Surface Severe Plastic Deformation for Improved Mechanical/Corrosion Properties and Further Applications in the Bio-Medical and Hydrogen Sectors

2023

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“…Therefore, the biomineralization of HA onto surfaces of synthetic polymer scaffolds can form a bioactive surface with higher wettability and better osteoinductivity, which provides a more favorable microenvironment for osteoblast adhesion, proliferation, and differentiation [ 20 , 21 ]. Currently, soaking in a simulated body fluid (SBF) that contains similar ion levels to those of human body fluid is one of the most common biomineralization approaches and has the advantages of being a simple procedure and having high efficiency [ 22 ]. However, biomineralized coating fabricated by immersion in simulated body fluid is uneven and unstable.…”

Section: Introductionmentioning

confidence: 99%

Nano-Topographically Guided, Biomineralized, 3D-Printed Polycaprolactone Scaffolds with Urine-Derived Stem Cells for Promoting Bone Regeneration

Xing,

Shen,

Zhe

et al. 2024

Pharmaceutics

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Currently, biomineralization is widely used as a surface modification approach to obtain ideal material surfaces with complex hierarchical nanostructures, morphologies, unique biological functions, and categorized organizations. The fabrication of biomineralized coating for the surfaces of scaffolds, especially synthetic polymer scaffolds, can alter surface characteristics, provide a favorable microenvironment, release various bioactive substances, regulate the cellular behaviors of osteoblasts, and promote bone regeneration after implantation. However, the biomineralized coating fabricated by immersion in a simulated body fluid has the disadvantages of non-uniformity, instability, and limited capacity to act as an effective reservoir of bioactive ions for bone regeneration. In this study, in order to promote the osteoinductivity of 3D-printed PCL scaffolds, we optimized the surface biomineralization procedure by nano-topographical guidance. Compared with biomineralized coating constructed by the conventional method, the nano-topographically guided biomineralized coating possessed more mineral substances and firmly existed on the surface of scaffolds. Additionally, nano-topographically guided biomineralized coating possessed better protein adsorption and ion release capacities. To this end, the present work also demonstrated that nano-topographically guided biomineralized coating on the surface of 3D-printed PCL scaffolds can regulate the cellular behaviors of USCs, guide the osteogenic differentiation of USCs, and provide a biomimetic microenvironment for bone regeneration.

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“…On the contrary, the two-step method is extensively used for producing nanostructured materials like Al2O3 nanoparticles. [10]. The dry powder that is produced after using the physical and chemical processes is then dissolved in the base fluid (water).…”

Section: Introductionmentioning

confidence: 99%

Heat Transfer Analysis of Al_2O_3 Nanoparticles

Ali¹,

Afzal²,

Javaid³

et al. 2022

Proceedings of International Exchange and Innovation Conference on Engineering &Amp; Sciences (IEICES)

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The capability of temperature variation is essential for cooling industrial operations like transportation such as car and heavy vehicle radiators, electronics devices, petroleum industrial systems, etc. Different methods and fluids are used in the cooling process in industrial systems. The basic fluids are based on temperature, thermal stability, and the effectiveness of heat transmission. Thermal characteristics improve when nanoparticles are added to the basic fluid. Using Al2O3 nanofluid the heat transfer and variation in the temperature at the entrance side and outlet side of the microchannel pipe were studied. Through ANSYS Fluent, a well-defined method for utilizing Al2O3 nanofluids to investigate the impact of various performance optimization factors of nanofluids was performed. The temperature of the nanofluids at the inlet and outlet is found 300 K and 313.7 K, respectively during the simulation. The pressure drops from the inlet side to the outlet side as well a result that raising the temperature, heat coefficient, thermal conductivity, and viscosity of the base fluids when Al2O3 nanoparticles are added.

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Using a two-step method of surface mechanical attrition treatment and calcium ion implantation to promote the osteogenic activity of mesenchymal stem cells as well as biomineralization on a β-titanium surface

Abstract: Combination of the SMAT technique and Ca-ion implantation produced a β-titanium alloy with a bioactive surface layer, which was proved to effectively promote the osteogenic activity of MSCs and Ca–P mineral deposition in vitro.

Cited by 8 publications

References 66 publications

Surface Severe Plastic Deformation for Improved Mechanical/Corrosion Properties and Further Applications in the Bio-Medical and Hydrogen Sectors

Surface Severe Plastic Deformation for Improved Mechanical/Corrosion Properties and Further Applications in the Bio-Medical and Hydrogen Sectors

Nano-Topographically Guided, Biomineralized, 3D-Printed Polycaprolactone Scaffolds with Urine-Derived Stem Cells for Promoting Bone Regeneration

Heat Transfer Analysis of Al_2O_3 Nanoparticles

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