This study explores the transformative potential of E-learning in workplace safety and health training. This highlights the flexibility, accessibility, and cost-effectiveness of E-learning for both employers and employees. This study uses a multi-faceted approach, including literature review, case studies, expert interviews, technological assessment, and data analysis, to provide a comprehensive analysis. It also explores the use of emerging technologies such as Virtual Reality (VR), Augmented Reality (AR), and Artificial Intelligence (AI) in E-learning. The findings revealed that E-learning can enhance knowledge retention, reduce workplace accidents, and increase employee engagement. However, challenges such as technological barriers and resistance to new methods persist. The study concludes by recommending a gradual implementation approach, content customization, integration of emerging technologies, continuous assessment, and strategies to maintain high levels of employee engagement.