The large-scale integration of wind power and photovoltaics (PV) has increased the uncertainty in power system operation, posing challenges to energy balance. To enhance the flexibility and renewable energy integration capability of the new power system, a multi-timescale coordinated optimization method for microgrid generation-load-storage considering flexibility resource regulation potential is proposed. Based on the regulation potential of demand-side flexibility resources, their multi-timescale characteristics are utilized for operation and regulation. Simulation results confirm that the model can enhance the integration capability of renewable energy, smooth the load curve, and reduce system operating costs.