In Kazuo Ishiguro's novel "Klara and Sun" [1], Mr. Capaldi, a techno-optimist scientist, is hired by Josie's mother to create a robotic duplicate of her ill daughter, capable of harboring artificial consciousness and perpetuate her existence when she eventually dies. After reflecting on the complexities of human-AI (artificial intelligence) relationships, Mr. Capaldi talks to Klara, Josie's artificial friend, and observes: "They accept that your decisions, your recommendations, are sound and dependable, almost always correct. But they do not like not knowing how you arrive at them. That's where it comes from, this backlash, this prejudice."The subject of the human relationship with technology is anything but new, and the intersection between art, science, technology, and ethics is ancient, vast, and intricate. In fact, various "what ifs" or imaginative scenarios have found their way from paintings, sculptures, novels, and movies into real life through scientific and technological progress. Public health is no stranger to this phenomenon. More recently, the discussion surrounding AI and genomics (especially in conjunction with other data modalities) within public health constitutes a good example of the delicate balance between scientific advancement based on well-guided op-