Using artificial neural network for design and development of PVA/chitosan/starch/heparinized nZnO hydrogels for enhanced wound healing

Joorabloo, Alireza; Khorasani, Mohammad Taghi; Adeli, Hassan; Milan, Peiman Brouki; Amoupour, Moein

doi:10.1016/j.jiec.2021.12.027

Cited by 30 publications

(16 citation statements)

References 59 publications

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“…Wound healing is a complex physiological process; it is mainly divided into four stages: inflammation, cell proliferation, wound remodeling, and contraction. 1,2 During wound healing, tissue edema, thromboembolism, inflammation, and inactivation of growth factors will cause secondary damage to the damaged tissue, resulting in deeper wounds, 3 slower healing, and scarring, 4 it may even cause systemic inflammatory response syndrome (SIRS), which is life-threatening. 5−7 In recent years, skin tissue engineering techniques have greatly contributed to the development of wound healing.…”

Section: Introductionmentioning

confidence: 99%

“…Physical, chemical, and biological stimulation from the outside world will cause different degrees of damage to the structure and function of human skin. Wound healing is a complex physiological process; it is mainly divided into four stages: inflammation, cell proliferation, wound remodeling, and contraction. , During wound healing, tissue edema, thromboembolism, inflammation, and inactivation of growth factors will cause secondary damage to the damaged tissue, resulting in deeper wounds, slower healing, and scarring, it may even cause systemic inflammatory response syndrome (SIRS), which is life-threatening. − In recent years, skin tissue engineering techniques have greatly contributed to the development of wound healing. Acellular dermal matrix (ADM) has become the most representative wound dressing. , As a collagen-based scaffold material, type I collagen in pADM is the main component of the extracellular matrix (ECM).…”

Section: Introductionmentioning

confidence: 99%

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Heparinized Collagen Scaffolds Based on Schiff Base Bonds for Wound Dressings Accelerate Wound Healing without Scar

Feng

Dan

Zheng

et al. 2022

ACS Biomater. Sci. Eng.

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Skin wound healing is a complex process with multiple growth factors and cytokines participating and regulating each other. It is essential to develop novel wound dressings to accelerate the wound healing process. In this study, we developed the heparinized collagen scaffold materials (OL-pA), and the cross-linking reaction was based on the Schiff base reaction between pig acellular dermal matrix (pADM) and dialdehyde low molecular weight heparin (LMWH). Compared with pADM, the OL-pA modified by crosslinking still retained the triple helix structure of native collagen. When the dosage of the OL cross-linking agent was 12 wt %, the crosslinking density of OL-pA was 49.67%, the shrinkage temperature was 75.6 °C, the tensile strength was 14.62 MPa, the elongation at break was 53.14%, and the water contact angle was 25.1°, all of which were significantly improved compared with pADM. The cytocompatibility test showed that L929 cells adhered better on the surface of OL-pA scaffolds, and the proliferation ability of primary fibroblasts was enhanced. In vivo experiments showed that the OL-pA scaffolds could better accelerate wound healing, more effectively promote the positive expression of bFGF, PDGF, and VEGF growth factors, accelerate capillary angiogenesis, and promote wound scarless healing. In summary, the OL-pA scaffolds have more excellent hygrothermal stability, mechanical properties, hydrophilicity, and cytocompatibility. Especially the scaffolds have significant pro-healing properties for the full-thickness skin wound of rats and are expected to be a potential pro-healing collagen-based wound dressing.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Heparinized Collagen Scaffolds Based on Schiff Base Bonds for Wound Dressings Accelerate Wound Healing without Scar

Feng

Dan

Zheng

et al. 2022

ACS Biomater. Sci. Eng.

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“…The antibacterial and healing effects of the hydrogel of another mixed polymer composition, i.e., polyvinyl alcohol, chitosan and starch with addition of ZnO NPs (particle size below 30 nm) was studied [ 49 ]. E. coli (the ATCC 25922 strain) and S. aureus (the ATCC 25923 strain) were selected as the test microorganisms.…”

Section: Resultsmentioning

confidence: 99%

Nanoparticle-Containing Wound Dressing: Antimicrobial and Healing Effects

Yudaev

Mezhuev

Chistyakov

2022

Gels

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The dressings containing nanoparticles of metals and metal oxides are promising types of materials for wound repair. In such dressings, biocompatible and nontoxic hydrophilic polymers are used as a matrix. In the present review, we take a look at the anti-microbial effect of the nanoparticle-modified wound dressings against various microorganisms and evaluate their healing action. A detailed analysis of 31 sources published in 2021 and 2022 was performed. Furthermore, a trend for development of modern antibacterial wound-healing nanomaterials was shown as exemplified in publications starting from 2018. The review may be helpful for researchers working in the areas of biotechnology, medicine, epidemiology, material science and other fields aimed at the improvement of the quality of life.

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“…To improve the mechanical properties of hydrogels, this study added artificial polymer polyvinyl alcohol (PVA) to natural polymer hydrogels, which is a synthetic polymer commonly used to enhance the mechanical strength of hydrogels. It can be combined with polysaccharides to form hydrogels by freezing and thawing [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Influence of Molecular Weight of Polysaccharides from Laminaria japonica to LJP-Based Hydrogels: Anti-Inflammatory Activity in the Wound Healing Process

et al. 2022

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In this study, polysaccharides from Laminaria japonica (LJP) were produced by the treatment of ultraviolet/hydrogen peroxide (UV/H2O2) degradation into different molecular weights. Then, the degraded LJP were used to prepare LJP/chitosan/PVA hydrogel wound dressings. As the molecular weight of LJP decreased from 315 kDa to 20 kDa, the swelling ratio of the LJP-based hydrogels rose from 14.38 ± 0.60 to 20.47 ± 0.42 folds of the original weight. However, the mechanical properties of LJP-based hydrogels slightly decreased. With the extension of the UV/H2O2 degradation time, the molecular weight of LJP gradually decreased, and the anti-inflammatory activities of LJP-based hydrogels gradually increased. LJP that were degraded for 60 min (60-gel) showed the best inhibition effects on proinflammatory cytokines, while the contents of TNF-α, IL-6, and IL-1β decreased by 57.33%, 44.80%, and 67.72%, respectively, compared with the Model group. The above results suggested that low Mw LJP-based hydrogels showed great potential for a wound dressing application.

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Using artificial neural network for design and development of PVA/chitosan/starch/heparinized nZnO hydrogels for enhanced wound healing

Cited by 30 publications

References 59 publications

Heparinized Collagen Scaffolds Based on Schiff Base Bonds for Wound Dressings Accelerate Wound Healing without Scar

Heparinized Collagen Scaffolds Based on Schiff Base Bonds for Wound Dressings Accelerate Wound Healing without Scar

Nanoparticle-Containing Wound Dressing: Antimicrobial and Healing Effects

Influence of Molecular Weight of Polysaccharides from Laminaria japonica to LJP-Based Hydrogels: Anti-Inflammatory Activity in the Wound Healing Process

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