This systematic review examines whether the use of children’s literature in EFL classrooms supports the 4Cs of CLIL—content, communication, cognition, and culture. Previous research has shown many benefits for using children’s literature in English-dominant classroom settings, but it seems little attention has been given to its use in EFL contexts and no attention in CLIL. This study utilizes a systematic search strategy to collect and synthesize current research on children’s literature use in EFL settings in order to better understand how children’s literature may impact EFL student learning and, specifically, examine whether its use can meet the 4Cs of CLIL. Records from four databases were screened for studies using children’s literature in EFL settings, resulting in the inclusion of 15 articles. The analysis of the articles reveals that current research shows evidence that the use of children’s literature can help facilitate student learning in content, communication, cognition, and culture. However, despite this clear connection to the goals of CLIL, investigations on children’s literature remain absent from CLIL research. We believe this research lends support for the use of children’s literature in the CLIL classroom and calls for more attention, both by practitioners and researchers, toward the use of children’s literature in CLIL classrooms.