Using Blood and Plasma MicroRNAs as a Non-Invasive Biomarker in Patients with Colorectal Cancer

Stefanescu, Horatiu; Muntean, Delia; Pilut, Ciprian Nicolae; Diaconu, Mircea; Popescu, Roxana; Hutanu, Delia; Moise, Marius L.; Diana, Lighezan; Niţu, Răzvan; Popa-Cherecheanu, Alina; Negoiță, Silvius; Iovan, Ciprian V; Ungureanu, Emil; Calu, Valentin; Ciucă, Ioana

doi:10.7754/clin.lab.2017.170819

Cited by 2 publications

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“…These findings highlight the importance of the human endocrine system in the progression of OSCC (T-DOI II vs. T-DOI I and positive lymph-nodes vs. negative lymph-nodes). In addition, the findings of the present study are in line with those of other studies that depict the high importance of determining the melatonin serum concentration as a robust and reliable biochemical marker in the prevention, diagnosis and evolution assessment of different physiological or pathological conditions (35)(36)(37)(38). The results are based on an individual proficient and high-fidelity profile that is accurately modified on a daily circadian base, due to normal activities and light-dark cycles, modulating almost entirely the endocrine human environment.…”

Section: T-doisupporting

confidence: 91%

Clinical significance of serum melatonin in predicting the severity of oral squamous cell carcinoma

et al. 2019

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Melatonin, the primary hormone produced by the pineal gland, is intensely assessed for its anticancer properties. This study aimed to reveal the clinical significance of serum melatonin levels in predicting the severity of oral squamous cell carcinoma (OSCC). For this purpose, 40 male patients with OSCC and 30 healthy subjects were enrolled in this study. The serum levels of melatonin were determined by ELISA. The results revealed that the melatonin concentrations were significantly lower in the patients with OSCC compared with the controls (18.2 vs. 47.6 pg/ml, P<0.001). In addition, the serum melatonin levels had a high predictive accuracy for discriminating patients with OSCC with T-depth of invasion (DOI) II from the healthy controls (89.1%), as well as in discriminating patients with OSCC with nodal metastasis from those without nodal metastasis (83.8%). On the whole, the findings of this study suggest that the serum melatonin concentrations are closely related to the severity of OSCC and may thus be used to assess the different stages of oral cancer objectively and accurately. The present study also supports the conclusion that melatonin may be a potential therapeutic agent for use in the treatment of patients with OSCC.

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Section: T-doisupporting

confidence: 91%

Clinical significance of serum melatonin in predicting the severity of oral squamous cell carcinoma

et al. 2019

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“…Considering cost-effectiveness, a two-marker combination might be a better option for cervical cancer screening tests. Furthermore, detection based on serum measurements is more convenient and readily accepted and less invasive, which makes it ideal for the early detection of cancer (Stefanescu et al, 2018). Therefore, miR-521 and miR-638 might be regarded as potential screening biomarkers for cervical cancer.…”

Section: Discussionmentioning

confidence: 99%

Serum miR-638 Combined with Squamous Cell Carcinoma-Related Antigen as Potential Screening Biomarkers for Cervical Squamous Cell Carcinoma

Zheng

Liang

et al. 2020

Genetic Testing and Molecular Biomarkers

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Aims: Cervical cancer is the second most common cause of cancer-related deaths in developing nations. Human papillomavirus prophylactic vaccines are not widely available, and there are shortages of gynecologists and cytologists in the already overburdened health care systems. The aim of this study was to identify circulating microRNAs (miRNAs) that could be used as feasible screening tests for cervical cancer in low-resource regions. Materials and Methods: Serum expression levels of five miRNAs were measured and validated by quantitative real-time polymerase chain reaction in cervical squamous cell carcinoma (CSCC) patients, cervical intraepithelial neoplasia patients, and healthy individuals. Squamous cell carcinoma-related antigen (SCC-Ag) was also measured in the serum. Results: Serum miR-638, miR-203a-3p, miR-1914-5p, and miR-521 levels were downregulated in the CSCC group (p < 0.05). Receiver operating characteristic (ROC) curve analysis indicated that the area under the ROC curve (AUC) values for miR-638 and miR-521 were 0.734 and 0.742, respectively, for discriminating CSCC patients from healthy controls. Furthermore, the combined use of miR-638 and SCC-Ag yielded the best screening performance and increased the AUC value, sensitivity, and specificity to 0.956, 94.87%, and 80.00%, respectively. Conclusion: This study suggested that miR-638 and miR-521 have independent screening value and that the combined measurement of miR-638 and SCC-Ag resulted in a better ability to discriminate patients with CSCC from healthy individuals.

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Using Blood and Plasma MicroRNAs as a Non-Invasive Biomarker in Patients with Colorectal Cancer

Abstract: The expression of microRNAs can be successfully used in the evaluation and non-invasive monitoring of patients with CRC. However, further studies are needed regarding the expression of microRNAs and the connections these species have in the pathological mechanisms specific for CRC.

Cited by 2 publications

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Clinical significance of serum melatonin in predicting the severity of oral squamous cell carcinoma

Clinical significance of serum melatonin in predicting the severity of oral squamous cell carcinoma

Serum miR-638 Combined with Squamous Cell Carcinoma-Related Antigen as Potential Screening Biomarkers for Cervical Squamous Cell Carcinoma

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