As a fundamental knowledge source in a global learning environment, it is feasible to apply the relational database management systems (RDBMS), object-oriented database management systems (OODBMS), and other traditional DBMS. However, the traditional DBMSs are not feasible in semantic knowledge/ontology representation and inference. One of the reasonable ways to overcome the limitations is the semantic web-based business support framework. Especially, in this study, we focused on the development of semantic web ontology and natural language (NL)-based inference framework. To validate the efficiency of the proposed framework, we considered a reasonable scenario for course recommendation in a university.