Using coevolution to improve protein subfamily classification

Highlights from the 1st ISCB Latin American Student Council Symposium 2014

“…However, there is no single sequence similarity threshold that serves to accurately group proteins into isofunctional groups. Simonetti et al [ 14 ] showed us that the use of coevolution between aminoacids at sequence alignments may prove a useful tool to aid in the problem of protein subfamily classification.…”