Information diffusion methods (IDMs) often deal with “small sample problems” and distribute the information of one data point to its neighbors in fuzzy information processing. By considering new criteria, we establish an optimal model for parameters of IDMs to risk and decision analysis of fatal disease. We further illustrate a specific process and a successful application of IDMs by a more reasonable morbidity surface from one-dimensional and two-dimensional case studies of breast cancer analysis in Yanpu District, Shanghai