Using connectivity map to identify natural lignan justicidin A as a NF-κB suppressor

Drug repositioning is an important area of biomedical research. The drug repositioning studies have shifted to computational approaches. Large-scale perturbation databases, such as the Connectivity Map and the Library of Integrated Network-Based Cellular Signatures, contain a number of chemical-induced gene expression profiles and provide great opportunities for computational biology and drug repositioning. One reason is that the profiles provided by the Connectivity Map and the Library of Integrated Network-Based Cellular Signatures databases show an overall view of biological mechanism in drugs, diseases and genes. In this article, we provide a review of the two databases and their recent applications in drug repositioning.

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Using connectivity map to identify natural lignan justicidin A as a NF-κB suppressor

Cited by 2 publications

References 42 publications

Lignans and Neolignans: Plant secondary metabolites as a reservoir of biologically active substances

Lignans and Neolignans: Plant secondary metabolites as a reservoir of biologically active substances

A Review of Drug Repositioning Based Chemical-induced Cell Line Expression Data

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