Using Contrast-Enhanced MR Cholangiography with IV Mangafodipir Trisodium (Teslascan) to Evaluate Bile Duct Leaks After Cholecystectomy: A Prospective Study of 11 Patients

Vitellas, Kenneth M.; El-Dieb, Adam; Vaswani, Kuldeep K.; Bennett, William F.; Fromkes, John J.; Bova, James G.

doi:10.2214/ajr.179.2.1790409

Cited by 73 publications

(39 citation statements)

References 31 publications

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“…Recent studies have shown the utility of contrastenhanced MRC especially in visualizing non-dilatated bile ducts (e.g., in living liver donors) and biliary leaks [4,5,11]. Currently, three different hepatobiliary contrast agents are available for contrast-enhanced MRC: mangafodipir trisodium (Mn-DPDP; Teslascan; GE Healthcare, Oslo, Norway), gadobenate dimeglumine (Gd-BOPTA; MultiHance, Bracco Imaging, Milan, Italy), and gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA, gadoxetic acid; Primovist, Bayer Schering Pharma, Berlin, Germany).…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies have shown that contrast-enhanced MRC is particularly useful for the evaluation of biliary tract abnormalities in healthy individuals (e.g., potential living liver donors), and in patients suspected to have a biliary leak [1,[3][4][5]. Although contrast-enhanced MRC is increasingly used by radiologists, there is paucity of data in the literature with regard to the degree and extent of biliary excretion of hepatobiliary contrast agents.…”

Section: Introductionmentioning

confidence: 99%

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Contrast-enhanced MR cholangiography with Gd-EOB-DTPA in patients with liver cirrhosis: visualization of the biliary ducts in comparison with patients with normal liver parenchyma

et al. 2008

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Contrast-enhanced MR cholangiography with Gd-EOB-DTPA in patients with liver cirrhosis: visualization of the biliary ducts in comparison with patients with normal liver parenchyma Abstract The purpose of this study was to assess the quality of biliary duct visualization using Gd-EOB-DTPA-enhanced magnetic resonance cholangiography (EOB-MRC) in patients with liver cirrhosis. Forty adult patients with liver cirrhosis (cirrhosis group) and 20 adult individuals with normal liver parenchyma (control group) underwent EOB-MRC using T1-weighted GRE imaging up to 180 min after Gd-EOB-DTPA administration. Two observers assessed the visualization of each biliary structure and the overall anatomical visualization of the biliary tree. Child-Pugh, MELD score and laboratory findings were compared. The grade of visualization for each evaluated biliary structure was statistically different in the two groups (P=0.004 to <0.001). The overall EOB-MRC quality was rated as sufficient for anatomical visualization of the biliary tree in all individuals of the control group 20 min after Gd-EOB-DTPA application, but in only 16/40 patients (40%) of the cirrhosis group within 30 min after application. Analysis of the ROC curves revealed that the cut-off values, for non-sufficient visualization of the biliary tree 20 min after Gd-EOB-DTPA application, were MELD scores ≥11 and total serum bilirubin levels ≥30 μmol/l. Consecutively, EOB-MRC in patients with liver cirrhosis resulted in a decreased or even non-visualization of the biliary tree in a substantial percentage of patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Contrast-enhanced MR cholangiography with Gd-EOB-DTPA in patients with liver cirrhosis: visualization of the biliary ducts in comparison with patients with normal liver parenchyma

et al. 2008

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“…Vitellas et al [18] performed MR cholangiography with intravenous mangafodipir trisodium (Teslascan) in patients with a possible bile leak after cholecystectomy. Teslascan is a T1-weighted contrast agent that is excreted primarily through the biliary tract.…”

Section: Postoperative Detectionmentioning

confidence: 99%

Bile leaks from the duct of Luschka (subvesical duct): a review

Spanos

Syrakos

2006

Langenbecks Arch Surg

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Subvesical duct leaks occur after cholecystectomy regardless of gallbladder pathology or urgency of operation. They have been encountered more frequently in the era of laparoscopic cholecystectomy. Intraoperative cholangiography does not detect all such leaks. Staying close to the gallbladder wall during its removal from the fossa is the only known prophylactic measure. ERCP and stent placement are the most common effective diagnostic and therapeutic methods used. Intraoperative and perioperative adjunctive measures, such as fibrin glue instillation and pharmacologic relaxation of the sphincter of Oddi, can potentially be used in lowering the incidence of subvesical bile leaks.

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“…When suspected diagnosis can be made by endoscopic retrograde cholangiopancreatography (ERCP) which is gold standard examination for confirming the diagnosis. The disadvantages of this approach include invasiveness and a high rate of false-negatives [7]. In centers where MR cholangiography is the initial investigation of choice for biliary pathologies the detection rate is very high.…”

Section: Discussionmentioning

confidence: 99%

Double Gall Bladder—A Rare Entity

Agarwal¹,

Haldar²,

Agarwal

2011

Indian J Surg

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Cholecystectomy is the most commonly performed operation in surgery. Variations inanatomical disposition are not infrequent. However variations in number of cystic ductand gall bladder is quiet rare. This poses a diagnostic and management problem withcomplications during surgery and missed gall bladder being reported in world literature. We here by report a case of double gall bladder with double cystic duct that was managed by laparoscopic surgery.

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Using Contrast-Enhanced MR Cholangiography with IV Mangafodipir Trisodium (Teslascan) to Evaluate Bile Duct Leaks After Cholecystectomy: A Prospective Study of 11 Patients

Cited by 73 publications

References 31 publications

Contrast-enhanced MR cholangiography with Gd-EOB-DTPA in patients with liver cirrhosis: visualization of the biliary ducts in comparison with patients with normal liver parenchyma

Contrast-enhanced MR cholangiography with Gd-EOB-DTPA in patients with liver cirrhosis: visualization of the biliary ducts in comparison with patients with normal liver parenchyma

Bile leaks from the duct of Luschka (subvesical duct): a review

Double Gall Bladder—A Rare Entity

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