Youths with cerebral palsy encounter difficulties in target acquisition using mouse-based "point-and-click" tasks. The performance of "point-and-click computer tasks" by youths with cerebral palsy still needs improvement to allow easy target acquisition. The purpose of this study was to evaluate an algorithm intended to enhance the performance of point-andclick computer tasks for youths with cerebral palsy using a standard mouse. The curvature index-based algorithm for dynamic adjustment of control-display gain showed experimentally better performance during primary submovement, but worse performance during secondary correction sub-movements (higher number of sub-movements and longer movement time) for both typically developed youths and youths with cerebral palsy. It also showed better performance of average speed and maximum speed compared with Windows default settings. Furthermore, the average movement time, error rate, and overshoot rate for both typically developed youths and youths with cerebral palsy are higher using the curvature index-based algorithm.