Using Date Seed Powder Nanoparticles and Infusion as a Sustainable Source of Nutraceuticals

Abstract

Egypt is the world's largest date producing country. Different functional foods pertaining to date seeds were attempted before. Phenolic phytochemicals are not well absorbed in gastrointestinal tract, which results in lower bioactivity. Nanotechnology helps to resolve poor oral bioavailability. Aim was to evaluate the in-vivo anti-inflammatory properties of date seed powder (DSP) nanoparticles (NPs) and infusion in rats fed a high fat diet (HFD). Twenty five Wistar rats were distributed among five groups; I (control), II (on HFD), III (on HFD and DSPNP1 1:5), IV (on HFD and DSPNP2 2:3), and V (on HFD and DSP infusion 1g/kg/day). Blood samples were tested for C-reactive protein (CRP), Serum amyloid-A (SAA), total cholesterol, HDL, albumin, creatinine, and some primary biochemical parameters. HFD induced significant elevations in cholesterol and inflammatory markers as compared to the controls; while, HDL, ALT, AST, creatinine and albumin showed no change in all rats. In all DSP treatment groups, total cholesterol levels were reduced significantly. Both DSP NPs and infusion caused significant decrease in CRP and SAA levels. DSP NPs exhibited the same anti-inflammatory effects as their free counterparts. Using polyvinyl alcohol NPs of DSP in a wt/wt ratio of 2 PVA: 3 DSP; resulted in an acceptable particle size and physicochemical properties.

Antioxidant properties of date seeds extract (Phoenix dactylifera L.) in alloxan induced damage in rats

“…The re-establishment of biomarkers of hepatic and renal function; found herein, supports findings reported by Salama et al (2019) who found that DSPK intake reduces levels of glucose, T-cholesterol, triglycerides, and the main indicators of renal function in diabetic rats DSPK has been proved to act synergistically with insulin to reduce hyperglycemia and prevent secondary outcomes of diabetes mellitus such as cardiovascular events and anxiety (Bikri et al, 2021).…”

Interplay of Biochemical, Genetic, and Immunohistochemical Factors in the Etio-Pathogenesis of Gastric Ulcer in Rats: A Comparative Study of the Effect of Pomegranate Loaded Nanoparticles Versus Pomegranate Peel Extract

“…These positive surface charges of PLN were crucial in determining the electrostatic interactions and adhesion characteristics with the gastric mucosa. It was reported by Salama et al (2019) that the transport of nanoparticles that have positive charges through epithelial cellular membranes was greater than the molecules that have no or negative charges, hence, enhancing their bioavailability.…”

Current insights into date by-product valorization for sustainable food industries and technology

“…Additionally, Orabi and Shawky (2014) 194 reported a significant increase in mean corpuscular hemoglobin concentration (MCHC), hemoglobin level, and mean corpuscular hemoglobin (MCH), with a simultaneous decrease in testicular malondialdehyde levels in male albino rats orally treated with 2 mL per kg per day of date seed extracts for 60 days. In another study, Amany Alsayed et al (2019) 195 evaluated the effects of 1 g per kg per day of date seed nanoparticles infused in Wistar rats as a nutraceutical. The authors confirmed that treatment with date seed extract significantly reduced total cholesterol levels, C-reactive protein, and serum amyloid-alpha in the experimental group compared to the control group.…”