Using Deep Learning Algorithms to Grade Hydronephrosis Severity: Toward a Clinical Adjunct

Smail, Lauren Christine; Dhindsa, Kiret; Braga, Luis H.; Becker, Sue; Sonnadara, Ranil

doi:10.3389/fped.2020.00001

Cited by 73 publications

(59 citation statements)

References 22 publications

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“…Virus antigen can bind to cells, leading to the release of various cytokines. 32 Consiglio et al have recently found different cytokine storms in Kawasaki disease and MIS-C. Lymphopenia and CRP were more pronounced at onset of COVID-19 in children, who later develop fulminant MIS-C. They also found different plasma protein patterns in MIS-C and Kawasaki.…”

Section: Discussionmentioning

confidence: 93%

Family Transmission of COVID-19 Including a Child with MIS-C and Acute Pancreatitis

Abbas¹,

Törnhage²

2021

IMCRJ

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Introduction Spread of the novel coronavirus SARS-CoV-2, since at least December 2019, has caused a pandemic. SARS-CoV-2 causes the disease COVID-19, which can affect several human organs. Abdominal pain is one of the known symptoms, but little is known about acute pancreatitis as a complication. As well, knowledge about viral transmission in families is limited. This case report describes MIS-C and acalculous acute pancreatitis in a child who was a member of a family in which four of five members had COVID-19. Case Report A previously healthy family was infected by SARS-CoV-2 from an unknown source. The 13-year-old daughter was infected by SARS-CoV-2 and symptomatic during two periods, with an asymptomatic interval in-between. During the first period, she had transient and mild upper respiratory symptoms which was followed four weeks later by a secondary severe illness. At that point, there was inflammation in multiple organs and signs of Multisystem Inflammatory Syndrome in Children (MIS-C) and a Kawasaki-like disease with skin rash, scalded skin in hands and conjunctivitis. Myocarditis, bronchopneumonia, pancreatitis, and hepatopathy without encephalopathy were noted. She required assisted ventilation for 5 days. There were laboratory signs of disseminated intravascular coagulopathy. The multisystem inflammation was treated with intravenous immunoglobulin (IVIG) once a day for four days and immunotherapy (high dose methylprednisolone (IV) once a day, for 12 days, then tapered over 4 weeks, anakinra (IV) four times daily for 12 days), low molecular weight heparin for 22 days and salicylates for 6 weeks leading to full restoration of health. The two brothers and mother in the family had mild to moderate COVID-19 infections. The father was not affected despite close contact with his children. The household transmission and clinical course and outcome are described. No further known COVID-19 infection occurred in the neighborhood during or immediately after the family cluster was discovered. Conclusion Penetrance and severity of COVID-19 can vary in family clusters. One adolescent showed a two-phase course with severe infection. This case report highlights MIS-C and acute pancreatitis as a complication associated with COVID-19 in children.

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Section: Discussionmentioning

confidence: 93%

Family Transmission of COVID-19 Including a Child with MIS-C and Acute Pancreatitis

Abbas¹,

Törnhage²

2021

IMCRJ

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“…The natural composition of breast milk is well recognized as the golden standard of infant nutrition [ 1 ] and is associated with long-term health benefits [ 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 ]. Studies have shown that exclusive breastfeeding is accompanied by a reduced risk for developing medical conditions during childhood such as gastrointestinal infections (e.g., necrotizing enterocolitis) [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

The Protective and Long-Lasting Effects of Human Milk Oligosaccharides on Cognition in Mammals

et al. 2020

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Over the last few years, research indicated that Human Milk Oligosaccharides (HMOs) may serve to enhance cognition during development. HMOs hereby provide an exciting avenue in the understanding of the molecular mechanisms that contribute to cognitive development. Therefore, this review aims to summarize the reported observations regarding the effects of HMOs on memory and cognition in rats, mice and piglets. Our main findings illustrate that the administration of fucosylated (single or combined with Lacto-N-neoTetraose (LNnT) and other oligosaccharides) and sialylated HMOs results in marked improvements in spatial memory and an accelerated learning rate in operant tasks. Such beneficial effects of HMOs on cognition already become apparent during infancy, especially when the behavioural tasks are cognitively more demanding. When animals age, its effects become increasingly more apparent in simpler tasks as well. Furthermore, the combination of HMOs with other oligosaccharides yields different effects on memory performance as opposed to single HMO administration. In addition, an enhanced hippocampal long-term potentiation (LTP) response both at a young and at a mature age are reported as well. These results point towards the possibility that HMOs administered either in singular or combination forms have long-lasting, beneficial effects on memory and cognition in mammals.

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“…Renal rSO 2 was measured in a subset of infants using neonatal sensors in both centers wrapped around the posterior-lateral flank right below the costal arch with the tip of the sensor pointing toward the spine ( 17 ). The cerebrorenal oxygenation ratio (CRR), based on rSO 2 , was calculated as an indicator of continued hemodynamic redistribution after birth ( 4 ).…”

Section: Methodsmentioning

confidence: 99%

Prenatal Use of Sildenafil in Fetal Growth Restriction and Its Effect on Neonatal Tissue Oxygenation—A Retrospective Analysis of Hemodynamic Data From Participants of the Dutch STRIDER Trial

et al. 2020

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Objective: Sildenafil is under investigation as a potential agent to improve uteroplacental perfusion in fetal growth restriction (FGR). However, the STRIDER RCT was halted after interim analysis due to futility and higher rates of persistent pulmonary hypertension and mortality in sildenafil-exposed neonates. This hypothesis-generating study within the Dutch STRIDER trial sought to understand what happened to these neonates by studying their regional tissue oxygen saturation (rSO2) within the first 72 h after birth.Methods: Pregnant women with FGR received 25 mg placebo or sildenafil thrice daily within the Dutch STRIDER trial. We retrospectively analyzed the cerebral and renal rSO2 monitored with near-infrared spectroscopy (NIRS) in a subset of neonates admitted to two participating neonatal intensive care units, in which NIRS is part of standard care. Secondarily, blood pressure and heart rate were analyzed to aid interpretation. Differences in oxygenation levels and interaction with time (slope) between placebo- and sildenafil-exposed groups were tested using mixed effects analyses with multiple comparisons tests.Results: Cerebral rSO2 levels were not different between treatment groups (79 vs. 77%; both n = 14) with comparable slopes. Sildenafil-exposed infants (n = 5) showed lower renal rSO2 than placebo-exposed infants (n = 6) during several time intervals on day one and two. At 69–72 h, however, the sildenafil group showed higher renal rSO2 than the placebo group. Initially, diastolic blood pressure was higher and heart rate lower in the sildenafil than the placebo group, which changed during day two.Conclusions: Although limited by sample size, our data suggest that prenatal sildenafil alters renal but not cerebral oxygenation in FGR neonates during the first 72 post-natal hours. The observed changes in renal oxygenation could reflect a vasoconstrictive rebound from sildenafil. Similar changes observed in accompanying vital parameters support this hypothesis.

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Using Deep Learning Algorithms to Grade Hydronephrosis Severity: Toward a Clinical Adjunct

Cited by 73 publications

References 22 publications

Family Transmission of COVID-19 Including a Child with MIS-C and Acute Pancreatitis

Family Transmission of COVID-19 Including a Child with MIS-C and Acute Pancreatitis

The Protective and Long-Lasting Effects of Human Milk Oligosaccharides on Cognition in Mammals

Prenatal Use of Sildenafil in Fetal Growth Restriction and Its Effect on Neonatal Tissue Oxygenation—A Retrospective Analysis of Hemodynamic Data From Participants of the Dutch STRIDER Trial

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