2021
DOI: 10.3389/fcell.2021.722066
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Using Dictyostelium to Advance Our Understanding of the Role of Medium Chain Fatty Acids in Health and Disease

Abstract: Ketogenic diets have been utilized for many years to improve health, and as a dietary approach for the treatment of a range of diseases, where the mechanism of these low carbohydrate and high fat diets is widely considered to be through the production of metabolic products of fat breakdown, called ketones. One of these diets, the medium chain triglyceride ketogenic diet, involves high fat dietary intake in the form of medium chain fatty acids (MCFAs), decanoic and octanoic acid, and is commonly used in enduran… Show more

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Cited by 8 publications
(4 citation statements)
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“…Importantly, D. discoideum is genetically tractable and a variety of expression constructs have been generated to facilitate studies on protein localization and function ( Levi et al, 2000 ; Kuspa, 2006 ; Veltman et al, 2009 ; Faix et al, 2013 ; Müller-Taubenberger and Ishikawa-Ankerhold, 2013 ; Friedrich et al, 2015 ; Yamashita et al, 2021 ). For these and other reasons, it has also been used as a high-throughput biomedical model for studying variety of human diseases ( Huber, 2021 ; Kirolos et al, 2021 ; Mathavarajah et al, 2021 ; Pain et al, 2021 ).…”
Section: Discussionmentioning
confidence: 99%
“…Importantly, D. discoideum is genetically tractable and a variety of expression constructs have been generated to facilitate studies on protein localization and function ( Levi et al, 2000 ; Kuspa, 2006 ; Veltman et al, 2009 ; Faix et al, 2013 ; Müller-Taubenberger and Ishikawa-Ankerhold, 2013 ; Friedrich et al, 2015 ; Yamashita et al, 2021 ). For these and other reasons, it has also been used as a high-throughput biomedical model for studying variety of human diseases ( Huber, 2021 ; Kirolos et al, 2021 ; Mathavarajah et al, 2021 ; Pain et al, 2021 ).…”
Section: Discussionmentioning
confidence: 99%
“…D. discoideum has been widely used as a tractable model to investigate molecular mechanisms for bioactive compounds as disease treatments [ 23 ]. Compounds investigated as disease treatments using D. discoideum include medium-chain fatty acids and cannabinoids in epilepsy, bipolar disorder, and multiple sclerosis treatment [ 24 , 25 , 26 , 27 , 28 ] and polyphenols in polycystic kidney disease and Alzheimer’s disease treatment [ 29 , 30 ].…”
Section: Introductionmentioning
confidence: 99%
“…The social amoeba D. discoideum is a eukaryotic microbe that is used as a biomedical model organism for studying a variety of human diseases, including the NCLs ( Huber, 2021 ; Kirolos et al, 2021 ; Mathavarajah et al, 2021 ; Pain et al, 2021 ). During the growth phase of the life cycle, haploid amoebae feed on nutrients and divide by mitosis ( Mathavarajah et al, 2017 ).…”
Section: Introductionmentioning
confidence: 99%