2023
DOI: 10.1177/0271678x231216142
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Using digital pathology to analyze the murine cerebrovasculature

Dana M Niedowicz,
Jenna L Gollihue,
Erica M Weekman
et al.

Abstract: Research on the cerebrovasculature may provide insights into brain health and disease. Immunohistochemical staining is one way to visualize blood vessels, and digital pathology has the potential to revolutionize the measurement of blood vessel parameters. These tools provide opportunities for translational mouse model research. However, mouse brain tissue presents a formidable set of technical challenges, including potentially high background staining and cross-reactivity of endogenous IgG. Formalin-fixed para… Show more

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