Limited resources combined with a desire t o reach as many people as possible often make direct response public service announcements an important tool in educational campaigns. To understand the impact of direct-response TV PSAs, and find ways to increase their effectiveness, this study examined 1 ] the effects of a highly targeted HIV prevention message o n young adults' knowledge, perceptions, and intentions; and 21 whether altering t w o PSA elements, the telephone number used and the length of time i t was displayed, would affect viewers' recall and intention responses. The results indicated exposure t o the PSA had no discernible effects on HIV-related knowledge, but did affect perceptions. Compared wirh an unexposed control group, students exposed to the PSA a) estimated seeing more HIV-and AIDS-related PSAs, b) rated the usefulness of TV PSAs lower, c] were more likely to rate their chances of contracting HIV as l o w or none (83 percent vs. 66 percent, p < ,051. and d) expressed less desire t o obtain more information. The use of an all-mnemonic phone "number" resulted in a threefold increase in recall of the CDC National AIDS Hotline phone number, but did not affect intentions to call. Overall, the results reaffirm the importance of deploying strategies that g o beyond reliance o n either a single PSA or TV PSAs alone to affect knowledge, perceptions, or intentions.