Using disease-burden method to evaluate the strategies for reduction of aflatoxin exposure in peanuts

Wang, Xin; You, Shu-Han; Lien, Keng‐Wen; Ling, Min‐Pei

doi:10.1016/j.toxlet.2019.07.006

Cited by 5 publications

(5 citation statements)

References 45 publications

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“…The discrepancy may be owing to the fact that only peanuts and peanut oil among oil in Chongqing municipality were included in that study, and the attributable exposure was merely 0.025 ng/kg bw/day ( Chen et al, 2022 ). An evaluation conducted in Taiwan of China indicated the total annual DALYs caused by AFT contamination was 4,110, equivalent to 24.63 DALYs per 100,000 persons per year, which was higher than our results ( Wang et al, 2019 ). The remarkable thing was that the HBsAg-positive rate of Taiwanese (17.3%) far above that of the population in Chongqing (4.18%).…”

Section: Discussioncontrasting

confidence: 97%

“…The cancer slope factor (SF) of “Liner by Slope Factor” model describes the dose–response relationship between AFT exposure and HCC incidence ( Wang et al, 2019 ; FDA/CFSAN, 2021 ). The SF was derived from cancer potency factor (PF) proposed by JECFA.…”

Section: Methodsmentioning

confidence: 99%

“…It could estimate the impact of various interventions applied at specific steps in the farm-to-table continuum on AFT contamination. In this study, AFT content was uniformly distributed in the food, and both the mass of food and AFT content were assumed to be unchanged throughout the whole process ( Wang et al, 2019 ). That is, the proportion of food contaminated with AFT per unit mass was 100% (initial and final prevalence) either before or after the process module running.…”

Section: Methodsmentioning

confidence: 99%

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Disease burden contributed by dietary exposure to aflatoxins in a mountainous city in Southwest China

Qin

Li²,

et al. 2023

Front. Microbiol.

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IntroductionAflatoxins (AFT) identified as a Group 1 human carcinogen naturally contaminate various types of food and could increase the risk of hepatocellular carcinoma (HCC) through dietary intake. Chongqing municipality is located in Southwest China with subtropical monsoon climate which is conducive to AFT contamination in crops. However, the burden of HCC caused by the dietary exposure of the population in Chongqing to AFT has not been quantified.MethodsThe burden of HCC was estimated in terms of Disability Adjusted Life Year (DALY) using FDA-iRISK software. Dietary exposure to AFT in three food categories including grain and its products, nuts and seeds, and spices was assessed.ResultsThe lifetime average daily dose (LADD) of AFT exposure for the population ranged from 2.40 to 8.25 ng/kg bw/day and 9.51 to 15.10 ng/kg bw/day at the mean and heavy (P95) AFT contamination levels, respectively. Among the three food categories, grain and its products contributed most to AFT exposure of the population. The estimated DALYs related to HCC induced by AFT were 162,000–556,000 and 641,000-1,020,000; the DALY rates were 6.47–22.20 and 25.59–40.72 per 100,000 persons per year; and the population attribution fractions (PAF) were 1.68–5.78% and 6.66–10.60%.DiscussionAlthough the burden of HCC caused by dietary AFT was estimated to be relatively low among the population, the overall health burden might be underestimated owing to the uncertainties of this dataset. Thus, the overall health burden associated with AFT intake should still be of concern in further studies.

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Section: Discussioncontrasting

confidence: 97%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Disease burden contributed by dietary exposure to aflatoxins in a mountainous city in Southwest China

Qin

Li²,

et al. 2023

Front. Microbiol.

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“…While combating the impact of climatic change on food availability is a long-run process, controlling the aflatoxin exposure through safety measures seems more attainable. The common aflatoxin reduction strategies that have been proposed include (i) good agricultural practice; (ii) biocontrol; (iii) proper packaging for storage; (iv) basic processing (shelling, sorting, and blanching); (v) and detoxification by ozonolysis and ultraviolet irradiation (75). Among all, basic processing was the most effective measure for reducing 39.6 % of all total disability-adjusted life years per year (75).…”

Section: Exposure Assessment and Risk Characterization Of Aflatoxinsmentioning

confidence: 99%

“…The common aflatoxin reduction strategies that have been proposed include (i) good agricultural practice; (ii) biocontrol; (iii) proper packaging for storage; (iv) basic processing (shelling, sorting, and blanching); (v) and detoxification by ozonolysis and ultraviolet irradiation (75). Among all, basic processing was the most effective measure for reducing 39.6 % of all total disability-adjusted life years per year (75). Besides that, aflatoxin biocontrol products have shown to effectively reduce aflatoxin content in crops by 70.0 % to 100.0 % as compared with non-treated crops (76).…”

Section: Exposure Assessment and Risk Characterization Of Aflatoxinsmentioning

confidence: 99%

Aflatoxin Occurrence, Food Regulations, Dietary Exposure, and Risk Assessment: A Mini Review from the Malaysian Perspective

Chang¹,

Saad²,

Jamaluddin³

et al. 2023

MJMHS

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Aflatoxins are ubiquitous and occur in food. Exposure to aflatoxins seriously impact the health of human and animal. It is concerning especially when aflatoxins are odourless, colourless, and tasteless that hardly be detected through naked eyes. Ingestion of aflatoxin-contaminated food contributes the major route of exposure. The present review is an update on the aflatoxin occurrence in food, aflatoxin regulations in food, and recent risk assessment of aflatoxin exposure in Malaysia. Peanuts and chili were more prone to aflatoxin contamination in Malaysia. The extreme weather experienced in Malaysia and global climatic change may worsen the aflatoxin contamination in food. The regulatory standards for aflatoxins imposed by Malaysia are less stringent than developed countries. The dietary exposure of aflatoxins among Malaysian was relatively high as compared with other Asia countries, ranging from 0.002 to 34.00 ng/kg body weight/day. Nonetheless, Malaysian population had low risk of aflatoxin-related liver cancer, with an estimated liver cancer risk of <1 cancer case/100,000 population/year.

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Economics applied to food safety

Focker

Fels-Klerx

2020

Current Opinion in Food Science

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Using disease-burden method to evaluate the strategies for reduction of aflatoxin exposure in peanuts

Cited by 5 publications

References 45 publications

Disease burden contributed by dietary exposure to aflatoxins in a mountainous city in Southwest China

Disease burden contributed by dietary exposure to aflatoxins in a mountainous city in Southwest China

Aflatoxin Occurrence, Food Regulations, Dietary Exposure, and Risk Assessment: A Mini Review from the Malaysian Perspective

Economics applied to food safety

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