Using DNA-encoded libraries of fragments for hit discovery of challenging therapeutic targets

Zhao, Guixian; Zhu, Mengping; Li, Yangfeng; Zhang, Gong; Li, Yizhou

doi:10.1080/17460441.2024.2354287

Expert Opinion on Drug Discovery

2024

DOI: 10.1080/17460441.2024.2354287

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Using DNA-encoded libraries of fragments for hit discovery of challenging therapeutic targets

Guixian Zhao,

Mengping Zhu,

Yangfeng Li

et al.

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Selenium(II)‐Nitrogen Exchange (SeNEx) Chemistry: A Good Chemistry Suitable for Nanomole‐Scale Parallel Synthesis, DNA‐encoded Library Synthesis and Bioconjugation

Hou,

et al. 2024

ChemBioChem

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The continuous development of click reactions with new connecting linkage is crucial for advancing the frontiers of click chemistry. Selenium‐nitrogen exchange (SeNEx) chemistry, a versatile chemistry in click chemistry, represents an all‐encompassing term for nucleophilic substitution events that replace nitrogen at an electrophilic selenium(II) center, enabling the flexible and efficient assembly of linkages around a Se(II) core. Several SeNEx chemistries have been developed inspired by the biochemical reaction between Ebselen and cysteine residue, and demonstrated significant potential in on‐plate nanomole‐scale parallel synthesis, selenium‐containing DNA‐encoded library (SeDEL) synthesis, as well as peptide and protein bioconjugation. This concept aims to present the origins, advancements, and applications of selenium(II)‐nitrogen exchange (SeNEx) chemistry while also outlining the potential directions for future research in this field.

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Selenium(II)‐Nitrogen Exchange (SeNEx) Chemistry: A Good Chemistry Suitable for Nanomole‐Scale Parallel Synthesis, DNA‐encoded Library Synthesis and Bioconjugation

Hou,

et al. 2024

ChemBioChem

View full text Add to dashboard Cite

show abstract

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Using DNA-encoded libraries of fragments for hit discovery of challenging therapeutic targets

Cited by 1 publication

References 126 publications

Selenium(II)‐Nitrogen Exchange (SeNEx) Chemistry: A Good Chemistry Suitable for Nanomole‐Scale Parallel Synthesis, DNA‐encoded Library Synthesis and Bioconjugation

Selenium(II)‐Nitrogen Exchange (SeNEx) Chemistry: A Good Chemistry Suitable for Nanomole‐Scale Parallel Synthesis, DNA‐encoded Library Synthesis and Bioconjugation

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