Using domperidone to induce and sustain hyperprolactinemia in late-pregnant gilts

Farmer, C.; Mathews, Alice T.; Hovey, Russell C.

doi:10.1016/j.domaniend.2018.05.004

Cited by 8 publications

(5 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Three of these articles reported the negative effects of PGF 2α drugs on lactation (5,19,20), three found that PGF 2α drugs had no significant effect on colostrum yield or piglet intake (4,21,22), one demonstrated that PGF 2α drugs could increase or decrease the content of certain cytokines to affect activity of colostrum (23), and one observed an increase in serum IgG concentration and weight gain in 3-day-old piglets (24). Previously, researchers have attempted to enhance the feed intake and milk yield of sows as well as the growth rate of piglets by employing various feed additives during the lactation period (25)(26)(27). This experiment aims to explore a novel pathway utilizing sex hormones to regulate the endocrine system and improve lactation performance during lactation.…”

Section: Discussionmentioning

confidence: 99%

Cloprostenol sodium improves reproductive performance of multiparous sows during lactation

Zhu,

Zhang,

Zhang

et al. 2024

Front. Vet. Sci.

View full text Add to dashboard Cite

This study aimed to determine the effect of prostaglandin F2α (PGF2α) analog (D-cloprostenol sodium and DL-cloprostenol sodium) administration on the milk yield of multiparous sows (MS) and piglet growth performance. In total, 320 Landrace×Yorkshire parturient MS were randomly divided into three groups on day 115 of pregnancy: without treatment (N = 50), with 75 μg D-cloprostenol sodium (N = 137), and with 200 μg DL-cloprostenol sodium (N = 133). After delivery, the sows treated with D-cloprostenol sodium and DL-cloprostenol sodium were randomly allocated into three subgroups, respectively: (i) no additional treatment after farrowing; (ii) administration of cloprostenol sodium at 3 h and 5 days after farrowing; and (iii) administration of cloprostenol sodium at 3 h, 5 days, and 10 days after farrowing. Cloprostenol sodium effectively induced sows to synchronize parturition approximately 23 h after administration and increased the daytime delivery rates (p < 0.05). Compared with DL-cloprostenol sodium, D-cloprostenol sodium shortened the farrowing duration and birth interval of sows for inducing farrowing (p < 0.05). Moreover, we observed that a single administration of both D-cloprostenol sodium and DL-cloprostenol sodium a day before delivery significantly reduced the rates of stillborn piglets type II in MS (p < 0.05). Compared to no treatment and single treatment with cloprostenol sodium, quartic treatments with cloprostenol sodium significantly increased the daily feed intake of MS, litter weight after weaning, and average daily gain of piglets (p < 0.05). Cloprostenol sodium improved the 21-day milk yield, with D-cloprostenol sodium showing the best effect, which increased lactation ability by 30.30% (176.72 kg vs. 135.63 kg) (p < 0.05). DL-cloprostenol sodium followed closely, increasing lactation ability by approximately 25.00% (169.71 kg vs. 135.63 kg) (p < 0.05). During lactation, sows administered with D-cloprostenol sodium observed increased serum prolactin levels. Compared to untreated sows, the sows administered with D-cloprostenol sodium and multiple DL-cloprostenol sodium visibly shortened the weaning-to-estrus interval (WEI) and weaning-to-service interval (WSI) (p < 0.05). Furthermore, quartic injections of D-cloprostenol sodium resulted in an 18 percentage point increase in the pregnancy rate of breeding sows compared to controls (82.61% vs. 64.58%) (p > 0.05). In summary, cloprostenol sodium could enhance the reproductive performance of MS, particularly in terms of lactation performance. Additionally, the effect of quartic injections of D-cloprostenol sodium was the most pronounced.

show abstract

Section: Discussionmentioning

confidence: 99%

Cloprostenol sodium improves reproductive performance of multiparous sows during lactation

Zhu,

Zhang,

Zhang

et al. 2024

Front. Vet. Sci.

View full text Add to dashboard Cite

show abstract

“…In sows at risk of PPDS, reduction of the systemic inflammatory response and support of milk production are beneficial. NSAID drugs, such as ketoprofen, dopamine antagonists, such as metoclopramide, and exogenous OXY seem to be promising (Caron et al, 2020; Farmer et al, 2017, 2019, 2021; Junior et al, 2006; Mathews et al, 2021; Sali et al, 2021; Viitasaari et al, 2013, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…Litters from females treated with MET had greater homogeneity and there was smaller dispersion of litter weight, based on piglet weight at 21 days of age. Another important function of prolactin, besides initiation and maintaining the lactation, is mammary gland development and differentiation of the alveolar epithelium within the mammary glands (Farmer & Hurley, 2015, 2019). Mammary gland development starts during the last third of pregnancy (Farmer & Hurley, 2015, 2019).…”

Section: Medical Interventions For Improving Reproductive Health Duri...mentioning

confidence: 99%

“…Another important function of prolactin, besides initiation and maintaining the lactation, is mammary gland development and differentiation of the alveolar epithelium within the mammary glands (Farmer & Hurley, 2015, 2019). Mammary gland development starts during the last third of pregnancy (Farmer & Hurley, 2015, 2019). Mathews et al (2021) investigated whether late gestational hyperprolactinemia in primiparous sows induced by feeding MET would enhance mammary epithelial differentiation, milk yield, and piglet growth rate.…”

Section: Medical Interventions For Improving Reproductive Health Duri...mentioning

confidence: 99%

“…Farmer et al (2019) and Caron et al (2020) investigated the effect of daily administration of DOM in the last third of pregnancy on mammary gland development in gilts. Farmer et al (2019) showed that the combined administration of DOM per os (0.5 mg/kg, twice daily on Days 89–91 of gestation) and intramuscular injections (0.5 mg/kg, daily from Days 90–109 of gestation) led to a rapid and sustained release of prolactin over 24 days in late‐pregnant gilts. Caron et al (2020) showed that IGF‐1 concentrations were greater during late gestation in DOM‐treated gilts.…”

Section: Medical Interventions For Improving Reproductive Health Duri...mentioning

confidence: 99%

See 2 more Smart Citations

Reproductive health of the sow during puerperium

Björkman

Kauffold

Kaiser

2022

Molecular Reproduction Devel

View full text Add to dashboard Cite

The modern hyperprolific sow is susceptible to metabolic disease and chronic inflammation. The most sensitive phase is parturition, when the sow experiences systemic inflammation and stress, and major changes in metabolism and endocrinology. Resolution of inflammation and stress needs to happen quickly to ensure good reproductive health during puerperium. If the sow fails to adapt to these changes, puerperal disease may occur. The economically most important puerperal disease complex is the postpartum dysgalactia syndrome (PPDS). Other puerperal diseases include infections of the urogenital tract. Diagnosis of PPDS and urogenital disease on‐farm is challenging but several diagnostic methods, including clinical examination, behavioral observations, ultrasonography and biomarkers are available. Ultrasonography is an excellent tool for monitoring the health of the urogenital tract, the mammary gland, and uterine involution and guide further diagnostic interventions. Biomarkers such as Chromogranin A, tumor necrosis factor‐α, and interleukin‐6 represent promising tools to monitor general health and the systemic state of inflammation and oxidative stress of the sow. Nonsteroidal anti‐inflammatory drugs, dopamine antagonists, and oxytocin are promising to address the symptoms of PPDS. Reducing of stress, improving nutrition and intestinal health, and supporting animal welfare‐friendly husbandry help in the prevention of PPDS.

show abstract

Effects of sustained hyperprolactinemia in late gestation on mammary development of gilts

Caron

Palin

Hovey

et al. 2020

Domestic Animal Endocrinology

View full text Add to dashboard Cite

Using domperidone to induce and sustain hyperprolactinemia in late-pregnant gilts

Cited by 8 publications

References 19 publications

Cloprostenol sodium improves reproductive performance of multiparous sows during lactation

Cloprostenol sodium improves reproductive performance of multiparous sows during lactation

Reproductive health of the sow during puerperium

Effects of sustained hyperprolactinemia in late gestation on mammary development of gilts

Contact Info

Product

Resources

About