2020
DOI: 10.1007/s40620-020-00869-z
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Using electronic AKI alerts to define the epidemiology of acute kidney injury in renal transplants

Abstract: Background Little is known regarding the impact of acute kidney injury (AKI) on renal transplant outcome. Our aim was to define the incidence and outcome of AKI in renal transplant patients using data collected from a national AKI electronic alert system Methods The study represents a prospective national cohort study collecting data on 1224 renal transplants recipients with a functioning renal transplant, between April 2015 and March 2019. Results Four hundred forty patients experienced at least one episode… Show more

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Cited by 4 publications
(3 citation statements)
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“…Our findings align with and further validate the results of these aforementioned studies. While existing reports suggest relationships between eGFR, IgA nephropathy, kidney neoplasm, diabetic nephropathy, and sepsis ( 26 29 ), our study did not identify significant connections among them. Several factors may explain these null findings: sample size limitations, population structure complexities, disease heterogeneity, and potential confounding or reverse causation inherent to observational studies could all play a role.…”
Section: Discussioncontrasting
confidence: 99%
“…Our findings align with and further validate the results of these aforementioned studies. While existing reports suggest relationships between eGFR, IgA nephropathy, kidney neoplasm, diabetic nephropathy, and sepsis ( 26 29 ), our study did not identify significant connections among them. Several factors may explain these null findings: sample size limitations, population structure complexities, disease heterogeneity, and potential confounding or reverse causation inherent to observational studies could all play a role.…”
Section: Discussioncontrasting
confidence: 99%
“… 30 Additionally, it is worth discussing how to identify patients who may benefit from warnings given that populations needing alerts are highly heterogeneous. 29 , 31 , 32 , 33 The application of AKI alerts in pregnant individuals, 34 kidney transplant recipients, 35 and coronary angiography populations 36 was explored in previous studies. In the future, by refining alert timing, content, methods, and interventions and AKI management, it is probable that AKI alert may still have a beneficial effect on the outcomes of patients.…”
Section: Discussionmentioning
confidence: 99%
“…In addition to its clinical and primary application, the aforementioned AKI alert system, which had been implemented by all laboratories in NHSW, also had the potential to be applied as a centralised system of data collection, to systematically collect national data on AKI. While this new large data source may have already been utilised to better understand the epidemiology of AKI, including by describing AKI identified in different patient populations and health-care settings, [6][7][8][9][10][11][12] and exploring its association with various risk factors, [13][14][15][16][17] it also offered further opportunity in the QI arena. To demonstrate this additional benefit, the work described here aimed to develop a tool which could be used to robustly and reliably measure, monitor, and compare the effectiveness of health-care interventions related to AKI across the entire Welsh NHS.…”
Section: Background (Context and Rationale)mentioning
confidence: 99%