Using Extracochlear Multichannel Electrical Stimulation to Relieve Tinnitus and Reverse Tinnitus-Related Auditory-Somatosensory Plasticity in the Cochlear Nucleus

Chen, Min; Min, Shiyao; Zhang, Chen; Hu, Xuerui; Li, Shufeng

doi:10.1111/ner.13506

Cited by 8 publications

(7 citation statements)

References 39 publications

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“…In our view, this means that the neuronal noise is maximally upregulated (i.e., disinhibited, cf. Chen et al, 2022) around the TP, providing maximal hearing threshold improvement around that frequency range but maybe not limited to it (cf. Introduction).…”

Section: Discussionmentioning

confidence: 99%

“…In case of a reduced cochlear input due to inner hair cell damage (Tziridis et al, 2021) or denervation (‘hidden hearing loss’, Kujawa & Liberman, 2009), the added neuronal noise can lift the otherwise subthreshold cochlear input above the threshold (=SR), thereby improving hearing thresholds (Gollnast et al, 2017) or even speech perception (Schilling et al, 2022). For SR to optimize information transmission in the described way, the amplitude of the noise (i.e., the spike rate of the incoming uncorrelated neuronal noise) has to be constantly adapted to changing levels of cochlear input, most probably due to modulation of the inhibition (Chen et al, 2022). In our model, this optimization is achieved by maximizing the autocorrelation (AC) of the DCN output, that is, the spike rate (Krauss et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

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Is phase locking crucial to improve hearing thresholds in tinnitus patients?

Schulze

Tziridis

2023

Eur J of Neuroscience

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Temporal processing of auditory data plays a crucial role in our proposed model of tinnitus development through stochastic resonance (SR). The model assumes a physiological mechanism optimizing auditory information transmission (as quantified by autocorrelation [AC] analysis) into the brain by adding the optimal amount of neuronal noise to otherwise subthreshold signals. We hypothesize that this takes place at the second synapse of the auditory pathway in the dorsal cochlear nucleus (DCN). We propose that after hearing loss, this neuronal noise is increased in the affected frequency band to improve hearing thresholds at the cost of upward propagation of this added noise, which finally may be perceived as tinnitus. We already showed the improvement of hearing thresholds in a large population of patients. Until now, we did not investigate the differences in hearing thresholds based on the biological constraints of early auditory temporal processing (phase locking) that is only possible up to frequencies of 5 kHz. In this report, we grouped our patient database (N = 47,986) according to tinnitus pitch (TP) of below (TP <5kHz ) or above (TP >5kHz ) the 5 kHz limit or having no tinnitus (NT) and compared their mean audiograms. We found that TP <5kHz patients showed significantly better hearing thresholds than all other patient groups independent of age. No improvement was seen for TP >5kHz patients who even showed worse thresholds than NT patients for high frequencies. These results are further evidence for our SR model of tinnitus development and the existence of AC analysis at the level of the DCN.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Is phase locking crucial to improve hearing thresholds in tinnitus patients?

Schulze

Tziridis

2023

Eur J of Neuroscience

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“…1 Ausschnittsvergrößerung). Die Quelle für das neuronale Rauschen ist dabei hochwahrscheinlich im somatosensorischen System verortet [ 3 , 11 , 22 ], was z. B. auch erklärt, warum viele Patienten ihr Ohrgeräusch durch Anspannen der Kiefermuskulatur modulieren können.…”

Section: Das Erlanger Modell Der Tinnitusentstehungunclassified

“…Der Koinzidenzdetektor schließlich hemmt nun seinerseits den somatosensorischen Input [ 3 ]. Je größer der Informationsgehalt des DCN-Outputs ist, desto weniger Rauschen muss aus dem somatosensorischen System dem cochleären Input hinzuaddiert werden, um eine optimale Informationsübertragung zu gewährleisten.…”

Section: Das Erlanger Modell Der Tinnitusentstehungunclassified

The Erlangen model of tinnitus development—New perspective and treatment strategy

Schulze,

Schilling,

Krauss

et al. 2023

HNO

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Zusammenfassung Hintergrund Etwa ein Sechstel der Bevölkerung westlicher Industrienationen leidet unter chronischem subjektivem Tinnitus, der allein in Deutschland volkswirtschaftliche Behandlungs- und Folgekosten von fast 22 Mrd. € pro Jahr verursacht. Nach der vorherrschenden Auffassung entsteht Tinnitus als Folge eines durch Hörverlust ausgelösten maladaptiven neurophysiologischen Prozesses im Gehirn. Ziel der Arbeit Mit dem hier vorgelegten Erlanger Modell der Tinnitusentstehung wird ein umfassender neurophysiologischer Erklärungsansatz für das initiale Auftreten des Phantomgeräuschs nach Hörverlust vorgeschlagen. Auf der Grundlage des Modells wird eine neue Behandlungsstrategie entwickelt. Material und Methoden Das hier zusammenfassend vorgestellte Modell beruht auf verschiedenen tier- und humanphysiologischen Untersuchungen der letzten Jahre. Ergebnisse Das Erlanger Modell betrachtet subjektiven Tinnitus als Nebeneffekt eines physiologischen Mechanismus, der die Informationsübertragung in das auditorische System mittels stochastischer Resonanz (SR) auch im gesunden Hörsystem permanent optimiert. Tatsächlich hören hörgeschädigte Patienten mit Tinnitus im Mittel besser also solche ohne Tinnitus. Diese ungewohnte Perspektive auf das Phantomperzept kann betroffenen Patienten bereits dabei helfen, besser mit ihrem Leiden zurechtzukommen. Zusätzlich wurde, basierend auf dem Modell, als neue, individuell angepasste Behandlungsstrategie für tonalen Tinnitus die „low-intensity noise tinnitus suppression“ (LINTS) entwickelt und bereits erfolgreich an Patienten getestet. Schlussfolgerung Möglicher limitierender Faktor für Modell und Behandlungsstrategie ist die Tonhöhe des Tinnitusperzepts, die es für Frequenzen über rund 5 kHz nötig machen könnte, Anpassungen an der Behandlungsstrategie vorzunehmen.

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“…In case of a reduced cochlear input due to inner hair cell damage (Tziridis et al , 2021) or denervation ("hidden hearing loss", Kujawa & Liberman, 2009), the added neuronal noise can lift the otherwise subthreshold cochlear input above the threshold (= SR), thereby improving hearing thresholds (Gollnast et al , 2017) or even speech perception (Schilling et al , 2022). For SR to optimize information transmission in the described way, the amplitude of the noise (i.e., the spike rate of the incoming uncorrelated neuronal noise) has to be constantly adapted to changing levels of cochlear input, most probably due to modulation of the inhibition (Chen et al , 2022). In our model, this optimization is achieved by maximizing the autocorrelation (AC) of the DCN output, i.e., the spike rate (Krauss et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Is phase locking crucial to improve hearing thresholds in tinnitus patients?

Tziridis

Schulze

2023

Preprint

View full text Add to dashboard Cite

Temporal processing of auditory data plays a crucial role in our proposed model of tinnitus development through stochastic resonance (SR). The model assumes a physiological mechanism optimizing auditory information transmission (as quantified by autocorrelation (AC) analysis) into the brain by adding the optimal amount of neuronal noise to otherwise subthreshold signals. We hypothesize that this takes place at the second synapse of the auditory pathway in the dorsal cochlear nucleus (DCN). We propose that after hearing loss, this neuronal noise is increased in the affected frequency-band to improve hearing thresholds at the cost of upward propagation of this added noise, which finally may be perceived as tinnitus. We already showed the improvement of hearing thresholds in a large population of patients. Until now, we did not investigate the differences in hearing thresholds based on the biological constraints of early auditory temporal processing (phase locking) that is only possible up to frequencies of 5 kHz. In this report, we grouped our patient database (N=47986) according to tinnitus pitch (TP) of below (TP<5kHz) or above (TP>5kHz) the 5 kHz limit or having no tinnitus (NT) and compared their mean audiograms. We found that TP<5kHz patients showed significantly better hearing thresholds than all other patient groups independent of age. No improvement was seen for TP>5kHz patients who even showed worse thresholds than NT patients for high frequencies. These results are further evidence for our SR model of tinnitus development and the existence of AC analysis at the level of the DCN.

show abstract

Using Extracochlear Multichannel Electrical Stimulation to Relieve Tinnitus and Reverse Tinnitus-Related Auditory-Somatosensory Plasticity in the Cochlear Nucleus

Cited by 8 publications

References 39 publications

Is phase locking crucial to improve hearing thresholds in tinnitus patients?

Is phase locking crucial to improve hearing thresholds in tinnitus patients?

The Erlangen model of tinnitus development—New perspective and treatment strategy

Is phase locking crucial to improve hearing thresholds in tinnitus patients?

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