This article proposes a neural network-based system for prediction of computer user comfort with respect to the existing settings of the workstation. In this context, anthropometric measures and the existing measures of a computer workstation were related to back-support comfort, distance comfort, keyboard comfort, monitor comfort, and seat comfort using two distinct modeling approaches-multiple linear regression and artificial neural network. The purpose of this article was to compare and contrast the resulting models. The data from 144 computer workstations were used and a total of 12 different data types such as shoulder to elbow, eye to buttock, pan height, monitor height, or distance from the chair were recorded. While multiple linear regression could not be used to adequately predict the computer workstation comfort, the neural network was deemed superior. This approach allows ergonomists to aid in the decisionmaking process of computer environment design and the prediction of the health risk in an occupational environment.Computer-related repetitive disorders have become one of the largest problems facing ergonomists and the medical community because it is developing in epidemic proportions within the occupational environment. In previous years, the prevalence of neck and upper extremity complaints among computer users is high (Tittiranonda, Burastero, and Rempel 1999;Flodgren, Heiden, Lyskov, and Crenshaw 2007). Studies have shown that factors such as repetitive and stereotype movements, fixed postures, static load, insufficient recovery time, muscular fatigue, and psychosocial stress increase the risk of developing musculoskeletal symptoms (Flodgren et al. 2007;Tittiranonda et al. 1999;Jensen 2003;Juul-Kristensen, Søgaard, Strøyer, and Jensen 2004).In the wake of the expanding use of computers, concerns have been expressed about their potential health effects. Researches have shown