Using frozen section margin control technique to manage non-melanomatous skin lesions in high-risk sites

Nizamoglu, Metin; Douglas, Helen E.; McArdle, Ciarstan; Mathew, Bipin; Vize, Colin; Matteucci, Paolo

doi:10.1016/j.bjps.2015.12.023

Cited by 11 publications

(13 citation statements)

References 36 publications

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“…In general, variance in recurrence and metastasis rates of cSCC is influenced by treatment modality, patient and tumor characteristics, and duration of follow‐up. Firstly, regarding treatment modality, we found a recurrence rate of cSCC that compares well to recurrence rates described after surgical excision with bread‐loafing frozen section analysis (0‐10.3%) . General metastasis rates of cSCC range from 2% to 5% and have only been studied once after surgical excision with bread‐loafing frozen section analysis.…”

Section: Discussionsupporting

confidence: 60%

Effective excision of cutaneous squamous cell carcinoma of the face using analysis of intra‐operative frozen sections from the whole specimen

Hutting

Bos

Kibbelaar

et al. 2017

Journal of Surgical Oncology

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Section: Discussionsupporting

confidence: 60%

Effective excision of cutaneous squamous cell carcinoma of the face using analysis of intra‐operative frozen sections from the whole specimen

Hutting

Bos

Kibbelaar

et al. 2017

Journal of Surgical Oncology

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“…After a mean 1.3 stages of excision, complete excision was obtained in 98% of the patients and there was no recurrence at first year follow-up. 12 Moreover, 2 studies have utilized formalin-fixed tissue Mohs surgery, also referred to as slow Mohs , in patients with BCCs. They have reported 5-year-recurrrence rates of 0.58% and 2.8%, which are comparable to MMS.…”

Section: Discussionmentioning

confidence: 99%

Margin-Controlled, Staged Surgical Excision in the Treatment of High-Risk Basal Cell Carcinomas of the Head and Neck Region

Ucar¹,

Kocaaslan

Salman

et al. 2018

J Cutan Med Surg

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Background: The most common skin cancer is basal cell carcinoma (BCC), and the gold-standard treatment for high-risk tumours is Mohs surgery. However, alternative methods are needed for high-risk tumours in countries where the performance rate of Mohs surgery is low. Objectives: The objective of this article is to investigate the feasibility, efficacy, and safety of margin-controlled, staged surgical excision (MCSSE) in high-risk tumours as a possible treatment alternative. Methods: A retrospective cohort study, including patients diagnosed with high-risk BCC in the head and neck region and treated with MCSSE between 2003 and 2010, was conducted. Results: During the study period 50 tumours in 47 patients were treated, with low adverse event rates and high patient satisfaction rates. Of the 50 tumours, 1 recurred at the 12-month follow-up. Conclusions: Despite the small sample size and relatively short follow-up period, the present study shows that MCSSE might be a feasible alternative for the treatment of high-risk BCCs in institutions where Mohs surgery is not performed. Future studies on long-term recurrence rates are needed.

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“…50 Excision with en face margin analysis is similar to the Munich method, but the tissue is sectioned from the epidermis to the bottom and the deep margin may not be fully evaluated. 51 , 52 These methods aim to achieve a complete circumferential peripheral and deep margin assessment but are outside the scope of this article. Detailed descriptions of each method have been published.…”

Section: Wide Local Excision Compared To Mmsmentioning

confidence: 99%

“…Detailed descriptions of each method have been published. 47 , 48 , 49 , 50 , 51 , 52 As with any procedure, clearance and recurrence rates of these techniques may be dependent on the training and experience of the provider and proper tumor selection for the appropriate treatment technique. However, the ability of 100% deep and peripheral tumor margin assessment by the same doctor acting as surgeon and pathologist at the same time allows for the highest published cure rates and accurate clinicopathologic correlation in real-time.…”

Section: Wide Local Excision Compared To Mmsmentioning

confidence: 99%

Mohs micrographic surgery: a review of indications, technique, outcomes, and considerations

Bittner

Cerci

Kubo³

et al. 2021

Anais Brasileiros de Dermatologia

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Mohs micrographic surgery is a specialized form of skin cancer surgery that has the highest cure rates for several cutaneous malignancies. Certain skin cancers can have small extensions or “roots” that may be missed if an excised tumor is serially cross-sectioned in a “bread-loaf” fashion, commonly performed on excision specimens. The method of Mohs micrographic surgery is unique in that the dermatologist (Mohs surgeon) acts as both surgeon and pathologist, from the preoperative considerations until the reconstruction. Since Dr. Mohs’s initial work in the 1930s, the practice of Mohs micrographic surgery has become increasingly widespread among the dermatologic surgery community worldwide and is considered the treatment of choice for many common and uncommon cutaneous neoplasms. Mohs micrographic surgery spares the maximal amount of normal tissue and is a safe procedure with very few complications, most of them managed by Mohs surgeons in their offices. Mohs micrographic surgery is the standard of care for high risks basal cell carcinomas and cutaneous squamous cell carcinoma and is commonly and increasingly used for melanoma and other rare tumors with superior cure rates. This review better familiarizes the dermatologists with the technique, explains the difference between Mohs micrographic surgery and wide local excision, and discusses its main indications.

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Using frozen section margin control technique to manage non-melanomatous skin lesions in high-risk sites

Cited by 11 publications

References 36 publications

Effective excision of cutaneous squamous cell carcinoma of the face using analysis of intra‐operative frozen sections from the whole specimen

Effective excision of cutaneous squamous cell carcinoma of the face using analysis of intra‐operative frozen sections from the whole specimen

Margin-Controlled, Staged Surgical Excision in the Treatment of High-Risk Basal Cell Carcinomas of the Head and Neck Region

Mohs micrographic surgery: a review of indications, technique, outcomes, and considerations

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