Using ginseng for menopausal women's health care: A systematic review of randomized placebo-controlled trials

Lee, Hye Won; Ang, Lin; Lee, Myeong Soo

doi:10.1016/j.ctcp.2022.101615

Cited by 6 publications

(15 citation statements)

References 20 publications

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“…Polyphenols (Enokuchi et al, 2020;Taher et al, 2013;Terauchi et al, 2014) and botanical supplements, such as St John's Wort (Liu et al, 2014), evening primrose oil (Farzaneh et al, 2013;Kazemi et al, 2021), sage (Bommer et al, 2011), milk thistle (Saberi et al, 2020), ginseng (Lee et al, 2016(Lee et al, , 2022 and combined botanical supplements (Rattanatantikul et al, 2022) have been explored. Despite some studies reporting positive results, concerns about methodology, study heterogeneity and insufficient large-scale interventions mean it is not possible to conclude whether a causal relationship exists for reducing VMS.…”

Section: Other Botanical Supplementsmentioning

confidence: 99%

“…A combined supplement of isoflavone, black cohosh, chasteberry and evening primrose found no significant difference in sexual or bladder problems over a 12‐week period (Rattanatantikul et al, 2022), and flaxseed was not found to influence endometrium thickness in postmenopausal women (Simbalista et al, 2010). A systematic review of 15 RCTs reviewed the impact of different types of ginseng on menopausal women's health, and a meta‐analysis of three RCTs found that ginseng did not have a positive effect on either sexual function or endometrial thickness (Lee et al, 2022).…”

Section: Symptoms Of the Menopausementioning

confidence: 99%

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The role of diet in managing menopausal symptoms: A narrative review

et al. 2023

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Menopause is a natural stage that occurs when women stop menstruating, during which many women experience physical and psychological symptoms that can affect their quality of life and ability to work. Dietary modifications and food supplements may be explored by some women as alternatives to hormone replacement therapy, although existing reviews and expert position statements have given this limited consideration. This narrative review summarises the current evidence for dietary patterns, and botanical and food supplements, in the management of common menopausal symptoms, including vasomotor symptoms (VMS; hot flushes; night sweats), changes in bodyweight and composition, psychological symptoms (depression; anxiety; cognitive changes), sleep disturbances, joint pain, skin changes and urogenital symptoms. Soy isoflavones may reduce the frequency and/or severity of VMS, although results are inconsistent, and it is unclear whether dietary and supplemental sources have comparable effects. Adopting a healthier dietary pattern may support a healthy bodyweight and benefit VMS. However, evidence suggesting dietary patterns may benefit depression, anxiety, and cognition remains largely observational. While some botanicals, such as black cohosh and St John's Wort, have been reported in some studies to alleviate symptoms (such as VMS and depression), these are not currently recommended due to uncertainty about the appropriate dose and preparation, and potential safety concerns. Evidence for other symptoms is currently too limited to draw conclusions. While further trials at different menopausal stages are needed, adopting a healthier dietary pattern in accordance with dietary guidelines is likely to help support women's health before, during and after the menopausal transition.

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Section: Other Botanical Supplementsmentioning

confidence: 99%

Section: Symptoms Of the Menopausementioning

confidence: 99%

The role of diet in managing menopausal symptoms: A narrative review

et al. 2023

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“…Frontiers in Pharmacology frontiersin.org Ghavami et al, 2020;Miraghajani et al, 2020;Lee et al, 2021;Sha'ari et al, 2021;Ikeuchi et al, 2022;Lee et al, 2022;Luo and Huang, 2022;Naseri et al, 2022;Park et al, 2022;Zhu et al, 2022), whereas two focused on eligible combinations (such as with usual medication) (Duan et al, 2018;Zhu et al, 2021). Most studies reported the type of ginseng, which mainly included Panax ginseng, Panax notoginseng, Panax quinquefolius, and red ginseng.…”

Section: Literature Search and Characteristics Of The Included Studiesmentioning

confidence: 99%

Ginseng and health outcomes: an umbrella review

Wang

et al. 2023

Front. Pharmacol.

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Background: Ginseng consumption has been associated with various health outcomes. However, there are no review articles summarizing these reports.Methods: PubMed, Embase, the Cochrane Library of Systematic Reviews, Scopus, CNKI and Wanfang databases were searched from inception to 31 July 2022. The Assessment of Multiple Systematic Reviews-2 (AMSTAR-2) and Grading of Recommendations Assessment, Development and Evaluation (GRADE) systems were used to assess the methodological quality and quality of evidence in each meta-analysis, and the results were summarized in a narrative form.Results: Nineteen meta-analyses that met the eligibility criteria were identified from among 1,233 papers. The overall methodological quality was relatively poor, with only five studies being low-quality, and 14 critically low-quality. When compared with control treatments (mainly placebo), ginseng was beneficial for improving fatigue and physical function, sexual function, menopausal symptoms, metabolic indicators, inflammatory markers, unstable angina and respiratory diseases. Adverse events included gastrointestinal symptoms and potential bleeding; however, no serious adverse events were reported.Conclusion: This umbrella review suggests that ginseng intake has beneficial therapeutic effects for diverse diseases. However, the methodological quality of studies needs to be improved considerably. In addition, it is imperative to establish the clinical efficacy of ginseng through high-quality randomized controlled trials.

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“…13 Ginsenosides are known to have biological activity in maintaining homeostasis of the body and enhancing vital energy. 14 Being one of the most commonly used herbal dietary supplements and the most-studied herb for human physical performance, 15 ginseng has been used for centuries in traditional medicine to treat various diseases, such as cancer, 16 postmenopausal symptoms, 17 and erectile dysfunction. 18 The anti-fatigue effects of ginseng have already been documented in clinical practice and various animal-based experiments.…”

Section: Introductionmentioning

confidence: 99%

Ginseng for the Treatment of Chronic Fatigue Syndrome: A Systematic Review of Clinical Studies

Yang

Shin

Dabrh

et al. 2022

Glob Adv Health Med

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Background Chronic fatigue syndrome (CFS) is a complex and often disabling chronic condition emerging worldwide, with no curative or definitive therapy yet identified. Ginseng has been widely used to treat fatigue in other patient groups and conditions; however, a systematic review focusing solely on the impact of ginseng on fatigue in patients with CFS has not been performed. Objective This study aimed to assess the current state of evidence regarding ginseng for CFS. Methods Multiple databases were searched from inception to October 2020. All data was extracted independently and in duplicates. Outcomes of interest included the effectiveness and safety of ginseng in patients with CFS. Results 2 studies enrolling 68 patients were deemed eligible, including one randomized clinical trial and one prospective observational study. The certainty of evidence in the effectiveness outcome was low and moderate from both studies, while the safety evidence was very low as reported from one study. Conclusion Study findings highlight a potential benefit of ginseng therapy in the treatment of CFS. However, we are not able to draw firm conclusions due to limited clinical studies. The paucity of data warrants limited confidence. There is a need for future rigorous studies to provide further evidence.

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Using ginseng for menopausal women's health care: A systematic review of randomized placebo-controlled trials

Cited by 6 publications

References 20 publications

The role of diet in managing menopausal symptoms: A narrative review

The role of diet in managing menopausal symptoms: A narrative review

Ginseng and health outcomes: an umbrella review

Ginseng for the Treatment of Chronic Fatigue Syndrome: A Systematic Review of Clinical Studies

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