Using Global Criteria to Detect Malnutrition: Application in Disease States

Kirsch, Rachelle; Matthews, Kelsie; Williams, Valaree

doi:10.1002/ncp.10444

Cited by 15 publications

(12 citation statements)

References 103 publications

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“…Nutrition is important for the patients with advanced malignancy to receive chemotherapy. PG-SGA currently is the standard of patient assessment in oncology and other chronic catabolic condition [31]. In this study, the scores of PG-SGA were correlated to therapeutic responses of ICI.…”

Section: Discussionmentioning

confidence: 89%

Response Prediction in Immune Checkpoint Inhibitor Immunotherapy for Advanced Hepatocellular Carcinoma

Hung

Lee

Wang

et al. 2021

Cancers

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Immune checkpoint inhibitors (ICI) have been applied to treat advanced stage hepatocellular carcinoma (HCC) and obtain promising effects. However, tumor response to treatment was unpredictable. A predicting biomarker of objective response or disease-control is an unmet need for patient selection. In this study, 45 advanced HCC patients who failed to sorafenib treatment and received nivolumab, 3 mg/kg bi-weekly, were included. Tumor responses to nivolumab treatment were assessed by the modified response evaluation criteria in solid tumors (mRECIST) criteria. Tumor responses were correlated to clinical characteristics to find out response predictors. In this small series, the prevalence of extrahepatic nodal metastasis, distant metastasis, and portal vein thrombus among the patients were 22.2% (n = 10), 48.9% (n = 22), and 42.2% (n = 19), respectively. The pre-treatment tumor size was 7.2 ± 4.2 cm in maximal diameter, and the calculated total tumor volume was 619.0 ± 831.1 cm3. Among 45 patients, 3 patients had partial response (PR), 11 had stable disease (SD), and the other 31 had progression of disease. By correlating clinical data to the patients with PR and SD, serum neutrophil-to-lymphocyte ratio (NLR) (hazard ratio (HR) = 2.04) and patient-generated subjective global assessment (PG-SGA) score (HR = 2.30) were the independent factors in multivariate analysis. By receiver operating characteristic curve analysis, pre-treatment NLR ≤ 2.5 and PG-SGA score < 4 were the cutoff points to predict tumor response to ICI treatment. In conclusion, biomarkers to predict tumor response for HCC are still lacking in this costly ICI therapy. In this study, NLR ≤ 2.5 and PG-SGA score < 4 indicated disease-control, and can be applied as biomarkers to select the right patients to receive this costly therapy.

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Section: Discussionmentioning

confidence: 89%

Response Prediction in Immune Checkpoint Inhibitor Immunotherapy for Advanced Hepatocellular Carcinoma

Hung

Lee

Wang

et al. 2021

Cancers

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“…Similar effect was observed in acute pancreatitis patients, and the nutritional status of patients was also improved ( 23 ). Distinctive and complex metabolic changes after trauma make severe trauma patients more susceptible for developing malnutrition ( 6 , 24 ). One review further indicated that depending on the severity of injury, energy expenditure increased by 20–50% in trauma patients compared with patients after elective surgery ( 6 ).…”

Section: Discussionmentioning

confidence: 99%

Impact of early enteral nutrition on ventilator associated pneumonia in intubated severe trauma patients: A propensity score-matched study

et al. 2023

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BackgroundEarly enteral nutrition (EN) is recommended for critically ill patients. However, the impact of early EN on intubated severe trauma patients remains unclear.MethodsSeverely traumatized adult patients who received invasive mechanical ventilation (MV) for more than 48 h during intensive care unit (ICU) stay at our institution between 2017 and 2022 were retrospectively included. Early EN was defined as EN initiation ≤48 h from ICU admission and late EN >48 h. Propensity score matching (PSM) analysis was used to compare outcomes between the groups. The primary endpoint was the incidence of ventilator-associated pneumonia (VAP). Multivariable logistic regression analysis was performed to identify independent predictors of delayed EN.ResultsFor final analysis, 337 intubated severe trauma patients were available, including 204 (60.5%) in the early EN group and 133 (39.5%) in the late EN group. After PSM, early EN patients had a lower incidence of VAP (12.9 vs. 25.8%, p = 0.026) and a shorter length of hospital stay (21 vs. 24 days, p = 0.015) compared to late EN patients. There was no demonstrable difference in mortality between the two groups. Abdominal trauma, massive blood transfusion, and serum albumin were identified as independent risk factors for delayed EN.ConclusionEarly EN decreased the VAP rate and reduced the length of hospital stay in invasively ventilated patients with severe trauma. Abdominal injury, massive blood transfusion and low albumin were associated with delayed EN.

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“…190 Las herramientas de tamizaje validadas son: Nutritional Risk Screening 2002 (NRS-2002), Malnutrición Universal Screening Tool (MUST), Mini-Nutritional Assessment (MNA) en su forma completa o corta (MNA-SF), Malnutrición Screening Tool (MST) y Short Nutritional Assessment Questionnaire (SNAQ). 183,[191][192][193] La herramienta más adecuada es aquella que sea fácil de realizar, sensible a los cambios agudos y crónicos del Figura 1.…”

Section: Evaluación Y Requerimientos Nutricionalesunclassified

Recomendaciones para el diagnóstico y tratamiento del adenocarcinoma ductal de páncreas

Moro¹,

Alle²,

Basso³

et al. 2020

Acta gastroenterol. latinoam.

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Using Global Criteria to Detect Malnutrition: Application in Disease States

Cited by 15 publications

References 103 publications

Response Prediction in Immune Checkpoint Inhibitor Immunotherapy for Advanced Hepatocellular Carcinoma

Response Prediction in Immune Checkpoint Inhibitor Immunotherapy for Advanced Hepatocellular Carcinoma

Impact of early enteral nutrition on ventilator associated pneumonia in intubated severe trauma patients: A propensity score-matched study

Recomendaciones para el diagnóstico y tratamiento del adenocarcinoma ductal de páncreas

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