Using Helical CT to Evaluate Renal Cell Carcinoma in Patients Undergoing Hemodialysis: Value of Early Enhanced Images

Takebayashi, Shigeo; Hatta, Hideo; Chiba, Tetsuo; Takagi, Hidenobu; Koike, Shinji; Matsubara, Sho; Walsh, Patrick C.

doi:10.1016/s0022-5347(05)68369-3

Cited by 6 publications

(7 citation statements)

References 12 publications

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“…US appears to be less sensitive than CT for characterizing cysts but is similar for detecting solid tumours [23]. For RCC, early contrast‐enhanced CT might show higher sensitivity and specificity than delayed contrast CT [24]. At our institution, annual US screening for RCC is carried out in renal transplant recipients.…”

Section: Discussionmentioning

confidence: 99%

Features and outcomes of renal cell carcinoma of native kidneys in renal transplant recipients

Klatte¹,

Seitz

Waldert³

et al. 2010

BJU International

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Study Type – Therapy (case series) Level of Evidence 4 OBJECTIVE To outline the features and outcomes of renal cell carcinoma (RCC) in native kidneys of renal transplant recipients, who are at increased risk of developing this disease. PATIENTS AND METHODS We retrospectively studied the clinicopathological features and survival of 28 surgically treated RCCs, which developed in 24 renal transplant recipients. Features and outcomes were compared with 671 patients with RCC who had no renal transplant. RESULTS The median interval between renal transplantation and the occurrence of RCC was 5.6 years. Acquired cystic kidney disease was present in 83% of the transplanted patients. Compared with the patients with RCC and no renal transplant, RCCs of native kidneys in transplant recipients were more frequently incidental findings (92% vs 77%, P = 0.092), multifocal (39% vs 15%, P < 0.001), bilateral (17% vs 4%, P = 0.006), had lower T stages (P = 0.040), were smaller (P = 0.027), of lower grades (P = 0.010), were more frequently papillary (43% vs 19%, P = 0.019) and occurred at a significantly younger age (P = 0.022). After a median follow‐up of 6.7 years, eight renal transplant recipients had died (33%), but only two deaths were due to RCC. Survival with metastatic RCC was only 4 months, if a full resection of all metastatic sites was not achieved. In multivariate analysis the presence of a renal transplant had no effect on survival. CONCLUSIONS Most RCCs in renal transplant recipients are incidental low‐stage, low‐grade tumours with a favourable prognosis. The outstanding pathological findings are bilateral occurrence, papillary subtype and multifocality. Prognosis of metastatic RCC is poor but might be favourable if all metastases are resected. Screening for early detection of asymptomatic RCC is advocated.

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Section: Discussionmentioning

confidence: 99%

Features and outcomes of renal cell carcinoma of native kidneys in renal transplant recipients

Klatte¹,

Seitz

Waldert³

et al. 2010

BJU International

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“…DWI may be useful for the diagnosis of RCC in patients with ACDK. On conventional MRI (i.e., T1WI and T2WI) as well as CT, the numerous cysts visualized in the kidneys of ACDK patients can cause a false‐negative diagnosis of RCC . On DWIs at high b values, the SI of simple cysts is quite different from that of RCCs.…”

Section: Discussionmentioning

confidence: 99%

“…Gulanikar et al reported that the sensitivity of screening US for the diagnosis of RCC in patients with end‐stage renal disease (including those with ACDK) was 36.3 %. Consequently, it is generally agreed that contrast‐enhanced CT is the best imaging technique for the diagnosis of RCC in these patients . However, contrast‐enhanced CT involves problems such as radiation exposure, side effects of the contrast material, and acute volume overload caused by infusion in dialysis patients.…”

Section: Discussionmentioning

confidence: 99%

Renal cell carcinoma in patients with acquired cystic disease of the kidney: Assessment using a combination of T2‐weighted, diffusion‐weighted, and chemical‐shift MRI without the use of contrast material

Akita

Jinzaki

Akita

et al. 2013

Magnetic Resonance Imaging

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“…Th e CT diagnosis of cancer in patients with ACKD can be diffi cult due to the marked deformation of the renal architecture 30 . One author has demonstrated that early enhanced helical CT is superior to the delayed enhanced CT in the detection of RCC in ACKD patients 36,37 .…”

Section: Imagingmentioning

confidence: 99%

The Diagnosis of Urological Neoplasm in Dialysis Patients - a Brief Review

Merticariu¹,

Niculae²,

Merticariu³

et al. 2017

Rev. Med. Mod.

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Despite being closely monitored for their current and more acute pathology, cancer screening and in particular urological cancer screening is often neglected in patients with end stage renal disease undergoing dialysis. This review encompasses the diagnosis of urological malignancies that occur in end-stage renal patients after the initiation of hemodialysis. We conducted a literature search in PubMed and UpToDate databases using the diagnostic criteria for urological malignancies in hemodialysis patients. Based on the existing data in the current literature it seems that patients undergoing dialysis have a higher risk of developing cancer than the general population, with peculiarities in both cancer detection and investigation that need to be addressed. Further studies should be made in order to improve cancer screening and diagnosis in dialysis patients.

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Using Helical CT to Evaluate Renal Cell Carcinoma in Patients Undergoing Hemodialysis: Value of Early Enhanced Images

Cited by 6 publications

References 12 publications

Features and outcomes of renal cell carcinoma of native kidneys in renal transplant recipients

Features and outcomes of renal cell carcinoma of native kidneys in renal transplant recipients

Renal cell carcinoma in patients with acquired cystic disease of the kidney: Assessment using a combination of T2‐weighted, diffusion‐weighted, and chemical‐shift MRI without the use of contrast material

The Diagnosis of Urological Neoplasm in Dialysis Patients - a Brief Review

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