Using hemodynamic parameters quantified with computational fluid dynamics to explore potential mechanisms of occurrence and progression in Alzheimer Disease
Abstract:Background: It has gradually recognized that the patients with Alzheimer’s disease (AD) have cerebral hemodynamic disorders. The purpose of the present study was to exploit a novel computational fluid dynamics (CFD) model, which could be used to measure intracranial hemodynamics quantitively in AD patients and to further explore how the hemodynamic changes are involved in progression of AD.Methods: A novel CFD model was constructed by personal magnetic resonance angiography (MRA), vessel ultrasound and blood p… Show more
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