Using high-throughput sequencing to explore the anti-inflammatory effects of α-mangostin

Yin, Peng; Zou, Wenshu; Li, Jian Dong; Jin, Na; Gao, Qian; Li, Fenghua

doi:10.1038/s41598-019-52036-5

Cited by 14 publications

(13 citation statements)

References 81 publications

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“…The concentration and the method of administration of LPS were referred to Yin et al. ( Yin et al., 2019 ). The rats in the LPS group were injected LPS (10 mg/kg) intraperitoneally on day 13.…”

Section: Methodsmentioning

confidence: 99%

“…The rats in the control and PA groups received 20 ml/kg of drinking water and 200 mM PA, respectively, for 14 consecutive days. The concentration and the method of administration of LPS were referred to Yin et al (Yin et al, 2019). The rats in the LPS group were injected LPS (10 mg/kg) intraperitoneally on day 13.…”

Section: Experimental Animals and Managementmentioning

confidence: 99%

“…Immunohistochemistry was evaluated according to the methods described by Yin et al (2019). The expression of tight junction proteins of ileal tissues was assessed by immunohistochemistry.…”

Section: Immunohistochemistrymentioning

confidence: 99%

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Propionic Acid Targets the TLR4/NF-κB Signaling Pathway and Inhibits LPS-Induced Intestinal Barrier Dysfunction: In Vitro and In Vivo Studies

Yang

Xie

et al. 2020

Front. Pharmacol.

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Intestinal barrier dysfunction contributes to the development of intestinal diseases. Propionic acid (PA), a metabolite generated by anaerobic fermentation of dietary fiber in the intestinal cavity, has been proved to exert anti-inflammatory effects in a variety of diseases. However, the exact role of PA in LPS-induced intestinal barrier dysfunction is still unclear. Accordingly, we examined the latent mechanism of PA and its protective role in LPS-induced intestinal barrier dysfunction by both in vitro and in vivo experiments. In vitro, we identified that PA treatment could strongly promote cell migration, inhibit activation of NLRP3 inflammasome and maintain intestinal barrier function in LPS-induced IEC-6 cells, indicating the protective effect on the intestinal barrier function of PA. Further investigation of the mechanism involved revealed that PA could suppress the activation of TLR4/NF-kB pathway. In vivo, in a LPS-induced rat model, PA-induced protective effects in intestinal barrier dysfunction could be detected. In summary, our findings clarify the role of PA in intestinal barrier dysfunction and suggest that it is promising for the treatment of LPSrelated intestinal diseases.

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Section: Methodsmentioning

confidence: 99%

Section: Experimental Animals and Managementmentioning

confidence: 99%

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Propionic Acid Targets the TLR4/NF-κB Signaling Pathway and Inhibits LPS-Induced Intestinal Barrier Dysfunction: In Vitro and In Vivo Studies

Yang

Xie

et al. 2020

Front. Pharmacol.

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“…A recent study proposed a mechanism by which alpha-mangostin successfully modulated LPS-stimulated IEC-6 cell inflammation using a genome-wide examination of control, LPS-stimulated, and alpha-mangostin-pretreated cells. The study showed that α-MG pretreatment reduced LPS-induced expressions of NLRP3, caspase 1, interleukin (IL)-18, and IL-1β (121).…”

Section: Mangosteenmentioning

confidence: 99%

Selected Indonesian Medicinal Plants for the Management of Metabolic Syndrome: Molecular Basis and Recent Studies

Arozal

Louisa

Soetikno

2020

Front. Cardiovasc. Med.

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Increased prevalence of metabolic syndrome (MetS) in the world influences quality of health in all respective countries, including Indonesia. Data from Indonesian Family Life Survey reported in 2019 showed that the prevalence of MetS in Indonesia currently is 21.66%, estimated with the provincial incidence ranging up to 50%; additionally, the most common components of MetS discovered in Indonesia were poor high-density lipoprotein (HDL) cholesterol and hypertension. Management treatment of MetS involves a combination of lifestyle changes and pharmacological interventions to decrease cerebrovascular disease. Various natural substances have been shown to govern any cardiovascular or metabolic disorders through different mechanisms, such as triggering anti-inflammation, lipid profile correction, sensitization of insulin reception, or blood glucose control. In Indonesia, the utilization of natural compounds is part of the nation's culture. The community widely uses them; even though in general, their effectiveness and safety have not been thoroughly assessed by rigorous clinical trials. Scientific evidence suggested that cinnamon, mangosteen, and curcumin, as well as their derived components possess a broad spectrum of pharmacological activity. In this review, an enormous potential of cinnamon, mangosteen, and curcumin, which originated and are commonly used in Indonesia, could be treated against MetS, such as diabetes, hyperlipidemia, hypertension, and obesity. The findings suggested that cinnamon, mangosteen, curcumin and their derivatives may reflect areas of promise in the management of MetS.

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“…α-mangostin (α-MG) is a herbal medicine isolated from the pericarp of mangosteen fruits that has anti-inflammatory effects [ 76 ]. In a study conducted by Yin et al [ 77 ] its role in a rat model of colitis induced by LPS was evaluated. They showed that administration of α-MG ameliorated LPS-induced intestinal villi detachment, congestion, and hemorrhage.…”

Section: Inhibition Of the Nlrp3 Inflammasome Ameliorates Colitismentioning

confidence: 99%

Inflammasome Regulation: Therapeutic Potential for Inflammatory Bowel Disease

Zhou

Strober

et al. 2021

Molecules

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Inflammasomes are multiprotein complexes formed to regulate the maturation of pro-inflammatory caspases, in response to intracellular or extracellular stimulants. Accumulating studies showed that the inflammasomes are implicated in the pathogenesis of inflammatory bowel disease (IBD), although their activation is not a decisive factor for the development of IBD. Inflammasomes and related cytokines play an important role in the maintenance of gut immune homeostasis, while its overactivation might induce excess immune responses and consequently cause tissue damage in the gut. Emerging studies provide evidence that some genetic abnormalities might induce enhanced NLRP3 inflammasome activation and cause colitis. In these cases, the colonic inflammation can be ameliorated by blocking NLRP3 activation or its downstream cytokine IL-1β. A number of natural products were shown to play a role in preventing colon inflammation in various experimental colitis models. On the other hand, lack of inflammasome function also causes intestinal abnormalities. Thus, an appropriate regulation of inflammasomes might be a promising therapeutic strategy for IBD intervention. This review aims at summarizing the main findings in these studies and provide an outline for further studies that might contribute to our understanding of the role of inflammasomes in the pathogenesis and therapeutic treatment of IBD.

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Using high-throughput sequencing to explore the anti-inflammatory effects of α-mangostin

Cited by 14 publications

References 81 publications

Propionic Acid Targets the TLR4/NF-κB Signaling Pathway and Inhibits LPS-Induced Intestinal Barrier Dysfunction: In Vitro and In Vivo Studies

Propionic Acid Targets the TLR4/NF-κB Signaling Pathway and Inhibits LPS-Induced Intestinal Barrier Dysfunction: In Vitro and In Vivo Studies

Selected Indonesian Medicinal Plants for the Management of Metabolic Syndrome: Molecular Basis and Recent Studies

Inflammasome Regulation: Therapeutic Potential for Inflammatory Bowel Disease

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