“…Different integrative complementary and alternative medicine models have been developed in different countries for treatment of different conditions, for example, pain and stress disorders in Sweden 22 ; musculoskeletal disorders in the Royal London Hospital for Integrative Medicine, UK 23,24 ; geriatric disorders in Berlin, Germany 25 ; cancer treatment in Vienna, Austria 26,27 ; treating various health issues in Tuscany, Italy 28 ; psychological trauma and chronic disease in Australia 29 ; rheumatoid arthritis in Maharashtra, India 30 ; and so on. As has been suggested by the special panel at the Third International Research Congress on Integrative Medicine and Health in Portland, Oregon, in 2012, on different perspectives on Comparative Effectiveness Research, the same recommendations apply to improve integrated complementary and alternative medicine research, for example, need for innovation and controlling costs in large-scale studies, need to gather the input of stakeholders in shaping the framework for more informative, more decision maker–driven research, importance of balancing rigor and pragmatism, several examples of cost-effectiveness analyses, questions concerning the translation of evidence into practice, the effect of pragmatic trials on funding or policy, evidentiary distinctions between and among pragmatic trials and traditional randomized clinical trials, and the multiple roles of stakeholders, particularly in generating new information and knowledge.…”