Using Human Induced Neural Precursor Cells to Define Early Neurodevelopmental Defects in Syndromic and Idiopathic Autism

Connacher, Robert J.; DiCicco‐Bloom, Emanuel; Millonig, James H.

doi:10.1007/s40495-018-0155-0

Cited by 5 publications

(3 citation statements)

References 85 publications

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“…Our proliferation results are supported by other studies. Proliferation defects have been reported previously using iPSC-derived NPCs for both idiopathic ASD and other CNVs, such as 7q11.23 ( Mariani et al., 2015 ; Marchetto et al., 2017 ; Chailangkarn et al., 2016 ; Li et al., 2017 ; Turkalj et al., 2020 ; Prem et al., 2020 ; see Connacher et al., 2018 , for a review). Consistent with these data, numerous genetic studies have suggested that altered proliferation of cortical NPCs may be a potential cellular mechanism for autism risk ( Krishnan et al., 2016 ; Packer, 2016 ; Grove et al., 2019 ; Satterstrom et al., 2020 ).…”

Section: Discussionmentioning

confidence: 97%

Autism NPCs from both idiopathic and CNV 16p11.2 deletion patients exhibit dysregulation of proliferation and mitogenic responses

et al. 2022

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Section: Discussionmentioning

confidence: 97%

Autism NPCs from both idiopathic and CNV 16p11.2 deletion patients exhibit dysregulation of proliferation and mitogenic responses

et al. 2022

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“…Firstly, the effect of these mutations starts still in the process of the nervous system formation in the perinatal period and in early childhood as well. A number of mutations converge on the common path of the nervous system maturation in neurogenesis, axon development, and synapse formation [ 55 ] and these processes play a crucial role in the development of normal neuroplasticity [ 56 ].…”

Section: Systemic Approaches To the Study Of Autism Spectrum Disordersmentioning

confidence: 99%

Molecular Mechanisms of Aberrant Neuroplasticity in Autism Spectrum Disorders (Review)

Anashkina¹,

Ерлыкина²

2021

Sovrem Tehnol Med

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This review presents the analysis and systematization of modern data on the molecular mechanisms of autism spectrum disorders (ASD) development. Polyetiology and the multifactorial nature of ASD have been proved. The attempt has been made to jointly review and systematize current hypotheses of ASD pathogenesis at the molecular level from the standpoint of aberrant brain plasticity. The mechanism of glutamate excitotoxicity formation, the effect of imbalance of neuroactive amino acids and their derivatives, neurotransmitters, and hormones on the ASD formation have been considered in detail. The strengths and weaknesses of the proposed hypotheses have been analyzed from the standpoint of evidence-based medicine. The conclusion has been drawn on the leading role of glutamate excitotoxicity as a biochemical mechanism of aberrant neuroplasticity accompanied by oxidative stress and mitochondrial dysfunction. The mechanism of aberrant neuroplasticity has also been traced at the critical moments of the nervous system development taking into account the influence of various factors of the internal and external environment. New approaches to searching for ASD molecular markers have been considered.

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“…Namely, environmental and genetic factors seem to both have effects on the proliferation, migration, and differentiation of cells in the cerebral cortex. The utilization of iPSC-derived neural precursor cells can be a wonderful option for the study of the genetic and cellular properties of autism via these effects 16 .…”

Section: Ipscs In Autism Modellingmentioning

confidence: 99%

Utilization Avenues for Induced Pluripotent Stem Cells in Autism

Doenyas¹,

Laçin²

2019

Cumhuriyet Medical Journal

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Autism spectrum disorder (ASD) is a neurodevelopmental difference with increasing global prevalence. Yet, the etiology of ASD is still not unraveled. Individuals with ASD experience difficulties with social skills and communication, and exhibit repetitive and restrictive interests and behaviors. Method: There is yet no comprehensive model of autism that can explain all aspects of autism. Similarly, there exists no known treatment for it. Induced pluripotent stem cell (iPSC), which has been widely used in the regenerative treatment of many diseases in recent years, is promising for a better understanding of the causes of autism. Results: Autism modelling with iPSCs provides several opportunities for understanding the mechanisms underlying autism and developing personalized treatments. Conclusions: This review examines the use of iPSCs in ASD to date, their advantages, and the findings obtained via iPSC modeling of autism.

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Using Human Induced Neural Precursor Cells to Define Early Neurodevelopmental Defects in Syndromic and Idiopathic Autism

Cited by 5 publications

References 85 publications

Autism NPCs from both idiopathic and CNV 16p11.2 deletion patients exhibit dysregulation of proliferation and mitogenic responses

Autism NPCs from both idiopathic and CNV 16p11.2 deletion patients exhibit dysregulation of proliferation and mitogenic responses

Molecular Mechanisms of Aberrant Neuroplasticity in Autism Spectrum Disorders (Review)

Utilization Avenues for Induced Pluripotent Stem Cells in Autism

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