This commentary addresses three issues raised in the articles in this issue. First, conversations about replication efforts should begin with a reasonable and agreed-upon definition of what it means to say that a study did or did not replicate the results of another study. Second, if a replication failure has been identified, using the surface similarity of the studies to reverse-engineer an explanation is unlikely to be helpful. Finally, researchers and consumers should expect small and heterogeneous effects, and this fact points to the need to think meta-analytically.