This exploration aims to investigate the employment and entrepreneurship of college students. College students majoring in information and computing sciences in Xinxiang City are taken as the research object. A machine learning model for college students’ employment and entrepreneurship is established. Experiments are conducted using Python language and a machine learning framework. First, based on the employment and entrepreneurship indexes of college students in machine learning, the initial data of college students’ training quality evaluation are obtained from the educational administration system, library management system, college evaluation materials, and questionnaire survey. Then, the combination weighting method is adopted to determine the index weight, quantify the data, and modify the parameters of the data provided by the framework. The Gaussian kernel is selected as the kernel function, and the sample data used by the machine learning model are labeled. Finally, the sample data are employed to train and test the model. After the consistency test, the model reaches the optimal value after 7 iterations, with an error rate of 0.01 and an accuracy rate of 99%. The final error rate of entrepreneurship and innovation model based on machine learning is less than 0.1, which is consistent with the actual situation. The model can meet the requirements of college students’ entrepreneurship and employment evaluation. It proves that it can be applied to the research of college students’ employment and entrepreneurship and has certain theoretical guidance and practical significance for the evaluation of college students’ employment and entrepreneurship level.