Using Magnetic Resonance Angiography to Measure Abnormal Synovial Blood Vessels in Early Inflammatory Arthritis: A New Imaging Biomarker?

Vasanth, Lisa; Foo, Li Foong; Potter, Hollis G.; Adler, Ronald S.; Finzel, Kathleen C.; Pavlov, Helene; Mandl, Lisa A.

doi:10.3899/jrheum.090063

Cited by 27 publications

(19 citation statements)

References 25 publications

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“…Bone marrow oedema has been identified as a possible precursor to erosions and as an early marker of RA [23]. Dynamic T1-weighted imaging can be used to quantify synovial hyperperfusion reflecting arthritis activity [20,24], and MR angiography has been shown to depict abnormal vessels reflecting synovial neovascularisation [25]. Cartilage damage in RA has been demonstrated to be associated with physical disability, suggesting that effort should be invested in research in this field [26].…”

Section: Discussionmentioning

confidence: 98%

Cartilage quality in rheumatoid arthritis: comparison of T2* mapping, native T1 mapping, dGEMRIC, ΔR1 and value of pre-contrast imaging

et al. 2011

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Section: Discussionmentioning

confidence: 98%

Cartilage quality in rheumatoid arthritis: comparison of T2* mapping, native T1 mapping, dGEMRIC, ΔR1 and value of pre-contrast imaging

et al. 2011

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“…The use of MR angiography has also been proposed as a noninvasive biomarker to identify abnormal vasculature in patients with early inflammatory arthritis (83). Synovial angiogenesis is one of the earliest markers of inflammatory arthritis (84).…”

Section: Cartilage Imagingmentioning

confidence: 99%

Differential regulation of axonal growth and neuromuscular junction assembly by HGF/c‐Met signaling

Madhavan

Peng

2012

Developmental Dynamics

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Background: During vertebrate neuromuscular junction (NMJ) development, contact between motor axons and muscle fibers is followed by pre-and post-synaptic specialization. Using Xenopus nerve-muscle cocultures, we recently showed that spinal neurons initially contacted muscle cells by means of filopodial processes, and that muscle-derived basic fibroblast growth factor induced axonal filopodia and slowed axonal advance to promote nerve-muscle interaction and NMJ establishment. In contrast, neurotrophins enhanced axonal growth but suppressed the extension of axonal filopodia and blocked NMJ formation. Results: Here we report that hepatocyte growth factor (HGF), which also supports motor neuron survival, was expressed by Xenopus muscle cells, and that forced expression of HGF in Xenopus spinal neurons inhibited the extension of axonal filopodia. Overexpression of the HGF-receptor c-Met in neurons also blocked the formation of axonal filopodia and furthermore sped up axonal growth, but a kinase-dead form of c-Met was unable to effect these changes. Importantly, treatment of nerve-muscle cocultures with recombinant HGF or the expression of HGF or active c-Met in neurons, or that of excess HGF in muscle, inhibited nerve-induced AChR clustering in muscle. Conclusions: Our results suggest that HGF/c-Met signaling in neurons promotes axonal growth but suppresses filopodial assembly in neurons and hinders NMJ establishment. Developmental Dynamics 241:1562-1574,

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“…Diseases related to joints and bones are a major cause of morbidity in the population over 50 years old . Current imaging techniques have strengths and weaknesses for evaluating joint diseases . X ray and computed tomography (CT) can reconstruct hard tissues excellently, but they are insensitive to soft tissue lesions and use ionizing radiation.…”

Section: Introductionmentioning

confidence: 99%

Technical Note: Anti‐phase microwave illumination‐based thermoacoustic tomography of in vivo human finger joints

Chi

Huang

et al. 2019

Medical Physics

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Purpose Thermoacoustic tomography (TAT) has been studied to image joints. While several joint tissues could be thermoacoustically imaged, tendons and bone could not be recovered completely or clearly. The purpose of this study was to overcome this limitation. Methods We developed a novel TAT system based on anti‐phase microwave illumination method to image the proximal interphalangeal joint and middle phalanx of a right middle finger from a healthy volunteer. The performance of this new system for imaging joints and tendons was compared with that by in‐phase microwave illumination and a conventional pyramidal horn antenna. Results Anti‐phase microwave illumination can produce relatively homogeneous electric (E)‐Field distributions inside the joint tissues. The homogeneous E‐Field distributions can enhance the detectability of flexor tendon and extensor tendon. Anti‐phase microwave illumination could image the flexor tendon, and extensor tendon and bone, which were not clearly imaged by the in‐phase microwave illumination or by the horn antenna. The images generated by the in‐phase microwave illumination and pyramidal horn antenna were almost identical in terms of the tissue types they imaged. Conclusions Anti‐phase illumination can overcome the limitation associated with the conventional TAT by adding the ability of completely delineating tendons and bone in the joints. This study paves the way for us to continue the study and to validate its utility in detection of joint diseases.

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Using Magnetic Resonance Angiography to Measure Abnormal Synovial Blood Vessels in Early Inflammatory Arthritis: A New Imaging Biomarker?

Cited by 27 publications

References 25 publications

Cartilage quality in rheumatoid arthritis: comparison of T2* mapping, native T1 mapping, dGEMRIC, ΔR1 and value of pre-contrast imaging

Cartilage quality in rheumatoid arthritis: comparison of T2* mapping, native T1 mapping, dGEMRIC, ΔR1 and value of pre-contrast imaging

Differential regulation of axonal growth and neuromuscular junction assembly by HGF/c‐Met signaling

Technical Note: Anti‐phase microwave illumination‐based thermoacoustic tomography of in vivo human finger joints

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