Plastic materials account for about 20% of waste electrical and electronic equipment (WEEE). The recycling of this plastic fraction is a complex issue, heavily conditioned by the content of harmful additives, such as brominated flame retardants. Thus, the management and reprocessing of WEEE plastics pose environmental and human health concerns, mainly in developing countries, where informal recycling and disposal are practiced. The objective of this study was twofold. Firstly, it aimed to investigate some of the available options described in the literature for the re-use of WEEE plastic scraps in construction materials, a promising recycling route in the developing countries. Moreover, it presents an evaluation of the impact of these available end-of-life scenarios on the environment by means of the life cycle assessment (LCA) approach. In order to consider worker health and human and ecological risks, the LCA analysis focuses on ecotoxicity more than on climate change. The LCA evaluation confirmed that the plastic re-use in the construction sector has a lower toxicity impact on the environment and human health than common landfilling and incineration practices. It also shows that the unregulated handling and dismantling activities, as well as the re-use practices, contribute significantly to the impact of WEEE plastic treatments.