Using metabolomics to describe food in detail

Capozzi, Francesco; Trimigno, Alessia

doi:10.1016/b978-1-78242-084-2.00011-3

Cited by 8 publications

(10 citation statements)

References 51 publications

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“…This issue is particularly relevant for products with a broad spectrum of technological transformation, e.g., cheese. The validity of these FIBs for the ingestion of other types of cheese should thus be investigated [ 55 ].…”

Section: Discussionmentioning

confidence: 99%

GC-MS Based Metabolomics and NMR Spectroscopy Investigation of Food Intake Biomarkers for Milk and Cheese in Serum of Healthy Humans

et al. 2018

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The identification and validation of food intake biomarkers (FIBs) in human biofluids is a key objective for the evaluation of dietary intake. We report here the analysis of the GC-MS and 1H-NMR metabolomes of serum samples from a randomized cross-over study in 11 healthy volunteers having consumed isocaloric amounts of milk, cheese, and a soy drink as non-dairy alternative. Serum was collected at baseline, postprandially up to 6 h, and 24 h after consumption. A multivariate analysis of the untargeted serum metabolomes, combined with a targeted analysis of candidate FIBs previously reported in urine samples from the same study, identified galactitol, galactonate, and galactono-1,5-lactone (milk), 3-phenyllactic acid (cheese), and pinitol (soy drink) as candidate FIBs for these products. Serum metabolites not previously identified in the urine samples, e.g., 3-hydroxyisobutyrate after cheese intake, were detected. Finally, an analysis of the postprandial behavior of candidate FIBs, in particular the dairy fatty acids pentadecanoic acid and heptadecanoic acid, revealed specific kinetic patterns of relevance to their detection in future validation studies. Taken together, promising candidate FIBs for dairy intake appear to be lactose and metabolites thereof, for lactose-containing products, and microbial metabolites derived from amino acids, for fermented dairy products such as cheese.

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Section: Discussionmentioning

confidence: 99%

GC-MS Based Metabolomics and NMR Spectroscopy Investigation of Food Intake Biomarkers for Milk and Cheese in Serum of Healthy Humans

et al. 2018

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“…Organic products are generally more expensive than their conventional counterparts, which is why the increased prices generate the risk of fraud. Therefore, proper analytical techniques are required to assess the true organic origin of these foods (reviewed in [124]). As a rule, organic products are considered more safety and beneficial than conventional ones, but sometimes they could be more contaminated by microorganisms and biogenic amines as a result of application of manure for soil fertility improvement, and traces of antibiotics and fungicides could be detected as well.…”

Section: Metabolomicsmentioning

confidence: 99%

Plant organic farming research – current status and opportunities for future development

Tsvetkov

Atanassov

Vlahova

et al. 2018

Biotechnology & Biotechnological Equipment

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This paper reviews the recent development of the scientific, legislative, economic and environmental aspects of plant organic farming. The impact of organic farming on biodiversity and soil fertility is discussed in comparison with conventional systems. A significant barrier for wide application and future development of organic farming is the existing diversity of national and international policy instruments in this sector. Special attention is paid to up-to-date research techniques that could help solve a number of the problems typically faced in plant organic farming. It is argued that organic farming is still not productive enough to be considered fully sustainable. This underlines the necessity of strong support for more effective implementation of scientific research innovations and improvement of the networking between all stakeholdersorganic producers, scientists and corresponding policy makers at the national and international level.

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“…The effect of genotype and environmental factors on the food metabolome has been recently reviewed [27].…”

Section: The Food-intrinsic Metabolomementioning

confidence: 99%

NMR-Based Metabolomics: The Foodome and the Assessment of Dietary Exposure as a Key Step to Evaluate the Effect of Diet on Health

Capozzi¹

2018

Modern Magnetic Resonance

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NMR-based metabolomics has gained important insight into the associations between the metabolic status and health, as metabolomics signatures are found in blood, urine, stools, or saliva, differentiating healthy subjects from those affected by diseases or disorders. Although health status has been linked to diet, a measurable fingerprint is rarely found within the metabolome, demonstrating that the diet is curing or, at least, is modifying the subject metabolome away from or closer to a healthy status. The success in finding the correlation between the metabolome and a diet-related disease has, as the main obstacle, the inability to characterize the actual diet followed by the subject. Thus, a big scientific effort has been launched to find metabolite patterns which are characterizing precisely the personal food consumption in order to classify people according to their actual diet. Most of the studies based on NMR-metabolomics are focused on finding biomarkers within the dietary exposome, e.g., originating from food or gut microbiota, without a specific focus on the endogenous metabolome. The main drawback in such approach is a combination of: (i) the actual composition of the meal, (ii) the bioaccessibility of bioactive compounds, and (iii) the processing capability of the gut microbiota. In this chapter, these three aspects are illustrated, where NMR spectroscopy (effectively or potentially) gains relevant information in the discovery of biomarkers for the true food consumption, as a preliminary step in successful "dietary effect studies."

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Using metabolomics to describe food in detail

Cited by 8 publications

References 51 publications

GC-MS Based Metabolomics and NMR Spectroscopy Investigation of Food Intake Biomarkers for Milk and Cheese in Serum of Healthy Humans

GC-MS Based Metabolomics and NMR Spectroscopy Investigation of Food Intake Biomarkers for Milk and Cheese in Serum of Healthy Humans

Plant organic farming research – current status and opportunities for future development

NMR-Based Metabolomics: The Foodome and the Assessment of Dietary Exposure as a Key Step to Evaluate the Effect of Diet on Health

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