Using Microbiome-Based Approaches to Deprogram Chronic Disorders and Extend the Healthspan following Adverse Childhood Experiences

Abstract

Adverse childhood experiences (ACEs), which can include child trafficking, are known to program children for disrupted biological cycles, premature aging, microbiome dysbiosis, immune-inflammatory misregulation, and chronic disease multimorbidity. To date, the microbiome has not been a major focus of deprogramming efforts despite its emerging role in every aspect of ACE-related dysbiosis and dysfunction. This article examines: (1) the utility of incorporating microorganism-based, anti-aging approaches to combat ACE-programmed chronic diseases (also known as noncommunicable diseases and conditions, NCDs) and (2) microbiome regulation of core systems biology cycles that affect NCD comorbid risk. In this review, microbiota influence over three key cyclic rhythms (circadian cycles, the sleep cycle, and the lifespan/longevity cycle) as well as tissue inflammation and oxidative stress are discussed as an opportunity to deprogram ACE-driven chronic disorders. Microbiota, particularly those in the gut, have been shown to affect host–microbe interactions regulating the circadian clock, sleep quality, as well as immune function/senescence, and regulation of tissue inflammation. The microimmunosome is one of several systems biology targets of gut microbiota regulation. Furthermore, correcting misregulated inflammation and increased oxidative stress is key to protecting telomere length and lifespan/longevity and extending what has become known as the healthspan. This review article concludes that to reverse the tragedy of ACE-programmed NCDs and premature aging, managing the human holobiont microbiome should become a routine part of healthcare and preventative medicine across the life course.

Adverse childhood trauma and reoccurrence of illness impact the gut microbiome, which affects suicidal behaviors and the phenome of major depression: towards enterotypic-phenotypes

“…Recently, we discovered that ACE is connected with sensitized immunological and growth factor networks, nitro-oxidative stress, and antioxidant pathways (Maes et al, 2019; 2022b; Moraes et al, 2018). Consequently, it was postulated that the microimmuneoxysome is a potential therapeutic target for deprogramming the negative effects of ACEs (Dietert and Dietert, 2022). To the best of our knowledge, no research has linked changes in the microbiome to recurrent suicidal ideation or behaviours.…”

Microbes and Sustainable Living: Focus on Electric and Magnetic Fields

“…Another aspect of human sustainable life concerns the decades-long erosion of human health and functionality brought about by increasing disease burden. Rather than applauding a reasonable lifespan that is filled with ever increasely co-morbid chronic diseases and polypharmacy, we should be evaluating our progress toward sustainability with a different yardstick: by the length of our healthspan (days, week, months, or years spent in health) [6,138,139] not via a disease-ridden existence. An increasing number of prescription drugs consumed on a daily basis is not a sign of sustainable progress.…”

“…3) They regulate fear and risk of mental health issues [5]. 4) They affect circadian rhythm and sleep [6]. 5) They have the capacity to facilitate longevity [7].…”

The Embodied Microbiome

“…Aging [73][74][75][76] Microbiome status affects disease burden, sleep quality, Copyright© Rodney R Dietert about probiotic foods and the origins of chloroplasts to robust, vetted concepts of 2023 concerning microbes as fully cognitive beings that are supreme information gatherers making full use of quantum-based tools as they navigate the extremes of Earth and as well as our own body.…”