The leaf area index (LAI) describes the structure of vegetation and is a key variable for Earth system process modelling and ecohydrological models at regional and global scales. The Medium-Resolution Spectral Imager (MERSI) onboard China's new generation of polar-orbiting meteorological satellite series FengYun-3 (FY-3) can provide continuous and global observations of the land surface. Therefore, it could be a potential data source for global LAI retrieval. In this study, a LAI product was generated from FY-3B/MERSI data using the GLOBCARBON LAI algorithm. Cross-calibration of the FY-3B/MERSI spectral response function with Land Remote-Sensing Satellite (Landsat) Thematic Mapper (TM), allowed to correct the influence of the spectral response function difference on the inversion results. Field measurements of LAI and scale-converted LAI reference images provided by the ImagineS project were used to validate and inter-compare the FY-3B/MERSI LAI product with two widely used medium-resolution LAI products, GLOBMAP LAI product and Moderate Resolution Imaging Spectroradiometer (MODIS) LAI product (MYD15A2 H). The results demonstrate that FY-3B/MERSI LAI has the lowest uncertainty of the three products. The low uncertainty of FY-3B/MERSI LAI in shrub-grass mixed areas (root mean square error, RMSE = 0.07), in part, by the generally underestimated LAI value. For deciduous broadleaf forest, of the three products tested, FY-3B/MERSI LAI is closest to the LAI obtained from the reference image (coefficient of determination, R 2 = 0.70) and yields the lowest uncertainty (RMSE = 0.81). GLOBMAP (R 2 = 0.58), which uses the same algorithm, and surface cover data as FY-3B/MERSI LAI, significantly overestimates the LAI. This overestimation may partly due to the use of a relatively lower clumping index. MYD15A2H shows a relatively weak correlation with the reference data (R 2 = 0.25) and a higher uncertainty (RMSE = 1.45). For mature crops, all three LAI products display systematic underestimation of LAI. FY-3B/MERSI LAI yields the greatest underestimation (about 50%), followed by GLOBMAP (about 35%) and MYD15A2H (about 15%). Our inter-comparison of the three LAI products demonstrates that all have higher correlation for low LAI values. FY-3B/MERSI shows similar capabilities and quality to those of the MODIS sensor with respect to the top of atmosphere observations. However, different atmospheric correction processes may ARTICLE HISTORY