Cyber physical systems (CPSs) typically have numerous sensors monitoring the various physical processes involved. Some sensor failures are inevitable and may have catastrophic effects. The relational nature of the diverse measurands can be very useful in detecting faulty sensors, monitoring the health of the system, and reducing false alarms. This paper provides procedures on how one may integrate data from the various sensors, by careful design of a sensor relationship network. Once such a network has been adopted, choices become available in real time for enhancing the reliability, safety, and performance of the overall system.