Digital technologies like smartphones, social media, the internet, software applications, websites, and e-books are redefining the educational landscape, which was accentuated amid the COVID-19 pandemic. This chapter discussed the impact of digital technologies in enabling academic institutions to perform their noble responsibilities in delivering instructions virtually during the lockdown. The effects of using these technologies and the challenges encountered by developing countries in migrating to the digital environment amid the lockdown with particular reference to the educational ecosystem in Nigeria was the focal point in the chapter. Striking among these challenges is the issue of compatibility, the high cost of internet data, inadequate digital literacy skill, and environmental distraction. Thus, it was recommended that administrators of academic institutions and regulatory bodies such as the National Universities Commission (NUC) must provide lecturers and students at all levels with adequate training to ensure operational productivity in the use of digital technologies and resources.