Using optical tweezing to control phase separation and nucleation near a liquid–liquid critical point

Walton, Finlay; Wynne, Klaas

doi:10.1039/c9sm01297d

Cited by 22 publications

(28 citation statements)

References 82 publications

(134 reference statements)

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“…Solubility phase diagram of the compound, the good solvent and the antisolvent provides a guideline for determination of the solvent ratio for crystallization. [ 10,19,26,29,30 ] Lately, researchers started looking closely into the interface between the two liquid phases, [ 31–33 ] where the mass transfer and heat transfer occur, directly influencing formation of the droplets and crystallization.…”

Section: Introductionmentioning

confidence: 99%

Oiling‐Out Crystallization of Beta‐Alanine on Solid Surfaces Controlled by Solvent Exchange

Zhang

Wei

Choi

et al. 2020

Adv Materials Inter

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In this work, the solvent‐exchange crystallization processes of beta‐alanine in mixture of isopropanol and water on solid surfaces are reported. As the antisolvent isopropanol displaces the alanine solution pre‐filled in a microchamber, liquid–liquid phase separation occurs at the mixing front. The alanine‐rich subphase forms surface microdroplets that subsequently crystallize with during the solvent exchange. It is found that the flow rates and solid surfaces have significant influence on the droplet size, growth rate, and crystal size and morphology. At fast flow rates, the droplets solidify rapidly, forming spherical‐cap structures resembling the shape of droplets, in contrast to crystal microdomains or thin films formed at slow flow rates. On a highly hydrophilic surface, the crystals form thin film without droplets formation. It is further demonstrated that by the solvent exchange, the crystals, generated by using a stock solution with a very low concentration of the precursor, can be used as seeds to facilitate crystallization in bulk solution. The results suggest that the solvent exchange has the potential to be an effective approach for controlling oiling‐out crystallization, and to be wider applied in, such as, separation and purification of many food, medical, and therapeutic ingredients.

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Section: Introductionmentioning

confidence: 99%

Oiling‐Out Crystallization of Beta‐Alanine on Solid Surfaces Controlled by Solvent Exchange

Zhang

Wei

Choi

et al. 2020

Adv Materials Inter

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“…However, for macromolecules and molecular assemblies that have a larger α (resulting in larger potential well U trap ) optical trapping is feasible [7–9] . For example, Walton and Wynne clearly demonstrated phase separation and nucleation in a liquid mixture system (nitrobenzene/decane) by exploiting U trap [10, 11] . Sasaki and Masuhara et al.…”

Section: Introductionmentioning

confidence: 99%

“…[7][8][9] For example, Walton and Wynne clearly demonstrated phase separation and nucleation in a liquid mixture system (nitrobenzene/ decane) by exploiting U trap . [10,11] Sasaki and Masuhara et al also demonstrated the optical trapping of poly(N-isopropylacrylamide) (PNIPAM) in water facilitated by focusing a 1064 nm laser beam leading to the generation of F grad and a photothermal effect initiating a phase separation via coilglobule phase transition. [12][13][14][15] These trapping studies of molecular materials created new possibilities toward application of optical trapping for the nucleation and crystallization of organic and inorganic small molecules, [16,17] since optical trapping/optical tweezing can increase their local concentration.…”

Section: Introductionmentioning

confidence: 99%

Fluorescence Colour Control in Perylene‐Labeled Polymer Chains Trapped by Nanotextured Silicon

et al. 2022

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The ability to modulate, tune, and control fluorescence colour has attracted much attention in photonics‐related research fields. Thus far, it has been impossible to achieve fluorescence colour control (FCC) for material with a fixed structure, size, surrounding medium, and concentration. Here, we propose a novel approach to FCC using optical tweezers. We demonstrate an optical trapping technique using nanotextured Si (black‐Si) that can efficiently trap polymer chains. By increasing the laser intensity, the local concentration of perylene‐labelled water‐soluble polymer chains increased inside the trapping potential. Accordingly, the excimer fluorescence of perylene increased while the monomer fluorescence decreased, evidenced by a fluorescence colour change from blue to orange. Using nanostructure‐assisted optical tweezing, we demonstrate control of the relative intensity ratio of fluorescence of the two fluorophores, thus showing remote and reversible FCC of the polymer assembly.

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“…Since then, the field of (non-photochemical) laser-induced nucleation has expanded significantly [9][10][11][12][13][14][15] . The most recent work in this field has gone a step further by suggesting that the observed laser-induced effects have their origin in a laser-tweezing potential, or alternatively that they may stem from a stored electromagnetic energy that lowers the free energy [16][17][18] . Other studies of such passive chemical photonics includes non-resonant photocatalysis (alternatively termed dynamic Stark control), where intramolecular bond-breaking reactions have been catalysed in a plethora of molecules [19][20][21][22][23] .…”

Section: Introductionmentioning

confidence: 99%

Optically induced nanoscale forces: precipitating the separation of immiscible liquids

Andrews¹,

Forbes²

2020

Optical Trapping and Optical Micromanipulation XVII

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It is well known that the miscibility or immiscibility of dissimilar liquids can be a sensitive function of external physical conditions, and fractional composition. In regions of thermodynamic instability, phase separation can often be instigated by local nucleation, in regions of the fluid where fluctuations in concentration rise above a threshold value and compositional instabilities arise. Such fluctuations, normally stochastic, are strongly influenced by a dynamic interplay of local intermolecular forces. In fluid regions illuminated by off-resonance laser light, the forces between neighbouring molecules can be significantly modified by an 'optical binding' effect that depends on the polarizabilities of the components. In liquid mixtures, this enables the forces between molecules of the same, or different, chemical composition to be differentially modified. In consequence, a suitably guided laser beam can locally control nucleation events, and so precipitate phase separation.

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Using optical tweezing to control phase separation and nucleation near a liquid–liquid critical point

Abstract: Laser-induced phase separation (LIPS) and LIPS and nucleation (LIPSaN) harness fluctuations near a liquid–liquid critical point using optical tweezing and underlie the process of nonphotochemical laser-induced nucleation (NPLIN).

Cited by 22 publications

References 82 publications

Oiling‐Out Crystallization of Beta‐Alanine on Solid Surfaces Controlled by Solvent Exchange

Oiling‐Out Crystallization of Beta‐Alanine on Solid Surfaces Controlled by Solvent Exchange

Fluorescence Colour Control in Perylene‐Labeled Polymer Chains Trapped by Nanotextured Silicon

Optically induced nanoscale forces: precipitating the separation of immiscible liquids

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