Using Patch Testing to Improve Therapeutic Outcome in the Treatment of Hand Eczema in Vietnamese Patients

Abstract

BACKGROUND:Hand eczema is a common chronic and relapsing skin disease with various clinical features. Hand eczema aetiology can be allergic contact dermatitis (ACD), irritant contact dermatitis (ICD), atopic dermatitis (AD) and unknown or combination causes. If the causative agents are not detected treatment of hand eczema will be a failure. A patch test can be useful to detect causative agents in suspected allergic contact hand eczema. Then patients will avoid contacting them. This results in the improvement of hand eczema. In Vietnam, patch test has not been used before, so we conduct this study.AIM:To identify causative allergens by using patch test with 28 standard allergens in consecutive patients.METHODS:A group of 300 HE patients from the National Hospital of Dermatology and Venereology (NHDV) in Vietnam were enrolled in this study. They were divided into 4 groups-ACD, ICD, AD and unknown aetiology. The patient was patch tested with 28 standard allergens to identify the causative agents.RESULTS:Among the 300 HE enrolled patients, ACD accounted for 72.7%, AD and ICD had the same rate of 12.7%. 39.3% of the patients had a positive patch test. Reaction to nickel sulfate was the most common (10.3%), followed by potassium dichromate (9.7%), cobalt (4%) and fragrance mix (3.1%). About one-third of the cases had relevant clinical reactions correlated with the contact agents and clinical history. Males reacted to cement, thiuram mix and formaldehyde more than females, while females reacted to a nickel more than males.CONCLUSIONS:Hand eczema has variable clinical features and diverse aetiology. ACD is an important cause of hand eczema that can be managed with a patch test to detect causative allergens. Nearly 40% of HE cases had positive patch test. Relevant patch test reactions were seen in one-third of the patients. We propose using patch test detect causative agents in suspected allergic contact hand eczema. Then patients will avoid contacting them. This results in the improvement of hand eczema.

Pediatric chronic hand eczema: Epidemiology, clinical presentation, and management

“…16,22,35,49 In 2 studies, patch testing was reported to have clinical relevance of 78% in P-CHE and 76.2% in pediatric hand eczema, 22,50 which was much higher than that reported in adult studies. 51,52 The literature has not supported immunoglobulin E testing because no association has been found between positive specific immunoglobulin E during childhood and P-CHE. 17 The use of standardized severity assessments is rare in the P-CHE literature, with one P-CHE study using the Hand Eczema Severity Index and Investigator Global Assessment 24 and one study using the Hand Eczema Extent Score.…”