Using Preclinical Models to Understand the Neural Basis of Negative Urgency

Bardo, Michael T.; Weiss, Virginia G.; Rebec, George V.

doi:10.1016/b978-0-12-813693-5.00001-0

Cited by 4 publications

(8 citation statements)

References 64 publications

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“…There have been a few attempts to do this. A reward omission task was developed to translate and apply negative urgency in a preclinical model of negative urgency using rodents [115,116]. The initial study examined both human and animal models of a reward omission task to represent negative urgency-like behaviors in both species for back-translation [116].…”

Section: Applications To Treatment and Intervention And Suggestionmentioning

confidence: 99%

Shared Neural Correlates Underlying Addictive Disorders and Negative Urgency

Whitt

Revilla

et al. 2019

Brain Sciences

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Negative urgency is a personality trait reflecting the tendency to act rashly in response to extreme negative emotions and is considered a transdiagnostic endophenotype for problematic levels of addictive behaviors. Recent research has begun to identify the neural correlates of negative urgency, many of which appear to overlap with neural circuitry underlying addictive disorders associated with negative urgency. The goal of this qualitative review is to summarize the extant literature concerning the neural correlates of negative urgency, to compare these correlates with those implicated with addictive disorders, and to propose new ways to begin to leverage such findings in treatment and intervention approaches. We also address current limitations in the field and make recommendations for areas for future growth in this research domain. Patterns of structure and function in the ventral striatum, frontal regions, such as the prefrontal cortex (PFC) and orbitofrontal cortex (OFC), and amygdala are common across addictive disorders and are related to both real-world risky behaviors and self-report measures of negative urgency. We propose that the time has come to move past considering this trait and these disorders as completely separate entities, and instead for the field to consider how general patterns of convergence across these disorders can lead to a more transdiagnostic approach to treatment and intervention. We suggest future work utilize these convergent patterns in the development of animal models of negative urgency, in the identification and testing of prime pharmacological and physiological interventions, and as objective biomarkers to be used when testing behavioral, pharmacological, and physiological intervention effectiveness. Little empirical work has been done to date in these areas and advances in these nascent fields would advance understanding and applications of the neuroscience of negative urgency.

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Section: Applications To Treatment and Intervention And Suggestionmentioning

confidence: 99%

Shared Neural Correlates Underlying Addictive Disorders and Negative Urgency

Whitt

Revilla

et al. 2019

Brain Sciences

View full text Add to dashboard Cite

show abstract

“…Positive and negative urgency are well-documented in tasks that use monetary incentives (Mason, Dunton, Gearhardt, & Leventhal, 2020;Racine et al, 2015;Puhalla, Ammerman, Uyeji, Berman, & McCloskey, 2016;Bardo, Weiss, & Rebec, 2018). Following omission of an expected reward, subjects with high levels of negative urgency show very high levels of frustration and display greater impulsive behaviors than subjects who are low in negative urgency (Bardo, Weiss, & Rebec, 2018). The task-based measures of positive and negative urgency have shown similar results in animal and human studies.…”

Section: Introductionmentioning

confidence: 89%

“…Compared to children and adults with low positive and negative urgency scores, subjects with high scores on the field of positive and negative urgency respond undesirably to anticipation or omission of reward (Mason, Dunton, Gearhardt, & Leventhal, 2020;Racine et al, 2015;Puhalla, Ammerman, Uyeji, Berman, & McCloskey, 2016;Bardo, Weiss, & Rebec, 2018). Positive and negative urgency are well-documented in tasks that use monetary incentives (Mason, Dunton, Gearhardt, & Leventhal, 2020;Racine et al, 2015;Puhalla, Ammerman, Uyeji, Berman, & McCloskey, 2016;Bardo, Weiss, & Rebec, 2018). Following omission of an expected reward, subjects with high levels of negative urgency show very high levels of frustration and display greater impulsive behaviors than subjects who are low in negative urgency (Bardo, Weiss, & Rebec, 2018).…”

Section: Introductionmentioning

confidence: 99%

Racial Variation in the Association between Suicidal History and Positive and Negative Urgency among American Children

Assari¹

2020

JECS

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Background: Positive and negative urgency reflect specific facets of impulsivity and correlate with several health-related risk behaviors such as aggression, substance use, and suicide. Less is known about how positive and negative urgency are associated with suicidal behaviors of diverse racial groups.Aim: To investigate racial differences in the positive associations between positive and negative urgency and suicide in children in US. Materials and methods: This longitudinal study used the Adolescent Brain Cognitive Development (ABCD) study. Participants were 10535 American children between ages 9 and 10 years old who were followed for up to one year. The independent variable was suicide history. The primary outcomes were the positive and negative urgency measured by the Urgency, Premeditation (lack of), Perseverance (lack of), Sensation Seeking, Positive Urgency, Impulsive Behavior Scale (UPPS-SS). Mixed-effects regression models were used for data analysis.Results: In the overall sample, suicidality was associated with positive and negative urgency in children. Race showed a statistically significant interaction with suicidality on children’s positive and negative urgency, indicating stronger effects of suicidality on positive and negative urgency for White, compared to Black and Other/Mixed race children respectively. Conclusion: The effects of positive and negative urgency for suicidality of American children depend on race. White American children show the strongest links between positive and negative urgency and risk of suicide, while the effects of positive and negative urgency on children suicide are weaker for Black and Other/Mixed race children.

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“…[58][59][60][61][62] Compared to children and adults with low negative urgency, subjects with high negative urgency respond undesirably to reward omission in tasks that use monetary incentives. [63][64][65][66] Following omission of an expected reward, subjects with high levels of negative urgency show frustration and display impulsive behaviors. 66 This study compared the effects of PEA on negative urgency of male and female children in the US.…”

Section: Introductionmentioning

confidence: 99%

“…[63][64][65][66] Following omission of an expected reward, subjects with high levels of negative urgency show frustration and display impulsive behaviors. 66 This study compared the effects of PEA on negative urgency of male and female children in the US. While high PEA is expected to be associated with less negative urgency (Hypothesis 1), this effect may be stronger for males than females (Hypothesis 2).…”

Section: Introductionmentioning

confidence: 99%

Association Between Parental Educational Attainment and Children’s Negative Urgency: Sex Differences

Assari

2021

Int J Epidemiol Res

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Background and aims: Negative urgency reflects a specific facet of impulsivity and correlates with a wide range of health-related risk behaviors, including, but not limited to, problematic substance use. Negative urgency is also shaped by family socioeconomic position (SEP), such as parental educational attainment (PEA). This study aimed to explore sex differences regarding protective effects of PEA on children’s negative urgency in the US. Methods: This cross-sectional study used the Adolescent Brain Cognitive Development (ABCD) study data. Baseline ABCD data included 10,535 American children in the age range of 9-10 years old. The independent variable was PEA, treated as a 5-level categorical variable. The primary outcome was negative urgency measured by the Urgency, Premeditation, Perseverance, Sensation Seeking, Positive Urgency, Impulsive Behavior Scale (UPPS-SS). Mixed-effects regression models were applied for data analysis. Results: In sex-stratified regression models, high PEA was predictive of lower levels of negative urgency in female but not male children. In the overall sample, sex showed a statistically significant interaction with PEA on children’s negative urgency, indicating a stronger protective effect of high PEA for female compared to male children. Conclusion: PEA was a more salient determinant of negative urgency in female children than male ones. Our results also showed that American boys tend to have high levels of negative urgency, which is a risk factor of drug use, at all parental education levels.

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Using Preclinical Models to Understand the Neural Basis of Negative Urgency

Cited by 4 publications

References 64 publications

Shared Neural Correlates Underlying Addictive Disorders and Negative Urgency

Shared Neural Correlates Underlying Addictive Disorders and Negative Urgency

Racial Variation in the Association between Suicidal History and Positive and Negative Urgency among American Children

Association Between Parental Educational Attainment and Children’s Negative Urgency: Sex Differences

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