PurposeThis study aims to provide a methodology and tools to design new organizational processes and artificial intelligence (AI)-based scoring to optimize the resources management in healthcare units.Design/methodology/approachProcess design and process data-driven simulation: the processes are designed by the business process modeling and notation and the unified modeling language standards. Data processing is performed by Correlation matrix analysis and by Fuzzy c-Means data clustering. The matching between the two methods provides the most indicated final corrective actions of the “TO BE” organizational model.FindingsThis proposed method, experimentally applied in this work merging the lean management model (LMM), process mining (PM) and AI methods, named process mining organization (PMO) model (Rosa et al., 2023 (b)), is able to improve organizational processes of a hospitalization unit (HU) by developing three propaedeutic phases: (1) analysis of the current state of the processes (“AS IS”) by identifying the critical issues as bottlenecks of processes, (2) AI data processing able to provide additional classified and predicted information allowing the “TO BE” workflow process and (3) implementation of corrective actions suggested by the PMO in order to support strategic decision-making processes in the short, medium and long term by classifying an order of priority about the healthcare procedures/protocols to perform.Research limitations/implicationsThe main limitation of the proposed case study is in the limited number of available digital data to process. This aspect reduces the capability to interpret result. In any case, the proposed methodology is a “launch” work to define a new approach to integrate organizational processes including workflow design and AI scoring. Future work will be focused on managerial implications due to use of the discussed method: design and development of new human resource (HR) organizational protocols following data analysis to optimize costs and care services and to decrease injury compensation claims.Practical implicationsMain implications are in healthcare managerial scenarios: design and development of new HR organizational protocols following data analysis to optimize costs and care services and to decrease injury compensation claims.Social implicationsCare services optimization is addressed on HUs.Originality/valueThe design of HR organizational processes integrates AI-driven data decision-making processes. This case study examines AI-based innovation analytics addressed on resource efficiency.