Using Rapid Prototyping to Develop a Cell-Based Platform with Electrical Impedance Sensor Membranes for In Vitro RPMI2650 Nasal Nanotoxicology Monitoring

Vasconez Martinez, Mateo Gabriel; Reihs, Eva I.; Stuetz, Helene M.; Hafner, Astrid; Brandauer, Konstanze; Selinger, Florian; Schuller, Patrick; Bastus, Neus; Puntes, Victor; Frank, Johannes; Tomischko, Wolfgang; Frauenlob, Martin; Ertl, Peter; Resch, Christian; Bauer, Gerald; Povoden, Guenter; Rothbauer, Mario

doi:10.3390/bios14020107

Cited by 3 publications

(1 citation statement)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…SLA 3D printing was used to construct the chip components and bonded to a PET membrane using the double-sided tape cut with xurography. Overall, this research demonstrated how affordable and rapid fabrication methods can be beneficial as pre-screening tools [96].…”

Section: Applications Of Using Double-sided Tapementioning

confidence: 81%

Double-Sided Tape in Microfluidics: A Cost-Effective Method in Device Fabrication

Smith,

Sypabekova,

Kim

2024

Biosensors

View full text Add to dashboard Cite

The demand for easy-to-use, affordable, accessible, and reliable technology is increasing in biological, chemical, and medical research. Microfluidic devices have the potential to meet these standards by offering cost-effective, highly sensitive, and highly specific diagnostic tests with rapid performance and minimal sample volumes. Traditional microfluidic device fabrication methods, such as photolithography and soft lithography, are time-consuming and require specialized equipment and expertise, making them costly and less accessible to researchers and clinicians and limiting the applicability and potential of microfluidic devices. To address this, researchers have turned to using new low-cost materials, such as double-sided tape for microfluidic device fabrication, which offers simple and low-cost processes. The innovation of low-cost and easy-to-make microfluidic devices improves the potential for more devices to be transitioned from laboratories to commercialized products found in stores, offices, and homes. This review serves as a comprehensive summary of the growing interest in and use of double-sided tape-based microfluidic devices in the last 20 years. It discusses the advantages of using double-sided tape, the fabrication techniques used to create and bond microfluidic devices, and the limitations of this approach in certain applications.

show abstract

Section: Applications Of Using Double-sided Tapementioning

confidence: 81%

Double-Sided Tape in Microfluidics: A Cost-Effective Method in Device Fabrication

Smith,

Sypabekova,

Kim

2024

Biosensors

View full text Add to dashboard Cite

show abstract

Fundamentals, Fabrication, Engineering, and Prototyping Aspects of Bioelectronics and Biosensors for Biomedical Analysis

Thakur,

Kumari,

Kumar

et al. 2024

Biosensors for Personalized Healthcare

View full text Add to dashboard Cite

Development of a Flexible Sensor-Integrated Tissue Patch to Monitor Early Organ Rejection Processes Using Impedance Spectroscopy

Ertl,

Wladimir,

Sticker

et al. 2024

Biosensors

Self Cite

View full text Add to dashboard Cite

Heart failure represents a primary cause of hospitalization and mortality in both developed and developing countries, often necessitating heart transplantation as the only viable recovery path. Despite advances in transplantation medicine, organ rejection remains a significant post-operative challenge, traditionally monitored through invasive endomyocardial biopsies (EMB). This study introduces a rapid prototyping approach to organ rejection monitoring via a sensor-integrated flexible patch, employing electrical impedance spectroscopy (EIS) for the non-invasive, continuous assessment of resistive and capacitive changes indicative of tissue rejection processes. Utilizing titanium-dioxide-coated electrodes for contactless impedance sensing, this method aims to mitigate the limitations associated with EMB, including procedural risks and the psychological burden on patients. The biosensor’s design features, including electrode passivation and three-dimensional microelectrode protrusions, facilitate effective monitoring of cardiac rejection by aligning with the heart’s curvature and responding to muscle contractions. Evaluation of sensor performance utilized SPICE simulations, scanning electron microscopy, and cyclic voltammetry, alongside experimental validation using chicken heart tissue to simulate healthy and rejected states. The study highlights the potential of EIS in reducing the need for invasive biopsy procedures and offering a promising avenue for early detection and monitoring of organ rejection, with implications for patient care and healthcare resource utilization.

show abstract

Using Rapid Prototyping to Develop a Cell-Based Platform with Electrical Impedance Sensor Membranes for In Vitro RPMI2650 Nasal Nanotoxicology Monitoring

Cited by 3 publications

References 56 publications

Double-Sided Tape in Microfluidics: A Cost-Effective Method in Device Fabrication

Double-Sided Tape in Microfluidics: A Cost-Effective Method in Device Fabrication

Fundamentals, Fabrication, Engineering, and Prototyping Aspects of Bioelectronics and Biosensors for Biomedical Analysis

Development of a Flexible Sensor-Integrated Tissue Patch to Monitor Early Organ Rejection Processes Using Impedance Spectroscopy

Contact Info

Product

Resources

About