This study identified the reading comprehension difficulties of grade 10 students, their level of learning domains, and their reading comprehension level in Magsaysay, Occidental Mindoro using the mixed sequential exploratory method. There were 229 respondents randomly selected among the 564 grade 10 students of the four public secondary schools in Magsaysay, Occidental Mindoro for the school year 2023-2024. The qualitative data gathered from the interview underwent thematic analysis while the quantitative data employed statistical treatments such as frequency, weighted means, PLS-SEM, and WarpPLS version 7.0. Based on the results of the interview, six reading comprehension difficulties were extracted as the main themes from the respondents' narratives. This became the basis for constructing the survey questionnaire related to the difficulties in reading and it revealed that vocabulary, close reading, finding the main idea, and concentration had a significant relationship to the respondents' reading comprehension level. This study found that the majority of the respondents were at the Instructional Level based on the Phil-Iri profiling. Furthermore, when the learning domains were linked to the level of reading comprehension, only the psychomotor domain was found to have a direct connection. Based on the findings, the study concluded that almost half of the grade 10 students could comprehend though they found reading challenging but manageable. Therefore, it is recommended that teachers and educational leaders continue addressing the reading comprehension difficulties of the students by providing various techniques, exercising reading activities, and adopting online interactive strategies. Also, educational authorities may use the proposed plan to acquire the skill in reading comprehension.