UDL is not only substantiated in relation to interventions within the school system, but also to the fields of community awareness, advocacy, education, work, health, institutional strengthening, and empowerment of society, as well as prevention, support and protection of people with disabilities. In our work, we present the possible applications of the UDL, I apply the educational field and psychotherapy, namely psychological treatment for children, adolescents, and adults. What we seek to understand is whether the UDL is also applicable to psychotherapy with the possibility to design universal accessible psychotherapy. In connection with the three neural network proposed by the UDL model, in psychotherapy practice the clinician might observe why patients establish a significant connection with the proposed material during treatment, what is accessible and understood in relation to the content, and how the acquired knowledge and skills can be effectively translated into daily life. Clinicians shall respect the principle of "flexibility within fidelity" [1] that is to widen the multiple possibilities of presentation of material and content in order to meet the different needs of a plurality of patients, while complying with the evidence-based principles.